Fluorescent molecular imaging and dosimetry tools in photodynamic therapy

Brian W. Pogue, Kimberley S. Samkoe, Summer L. Gibbs-Strauss, Scott C. Davis

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Measurement of fluorescence and phosphorescence in vivo is readily used to quantify the concentration of specific species that are relevant to photodynamic therapy. However, the tools to make the data quantitatively accurate vary considerably between different applications. Sampling of the signal can be done with point samples, such as specialized fiber probes or from bulk regions with either imaging or sampling, and then in broad region image-guided manner. Each of these methods is described below, the application to imaging photosensitizer uptake is discussed, and developing methods to image molecular responses to therapy are outlined.

Original languageEnglish (US)
Title of host publicationPhotodynamic Therapy
Subtitle of host publicationMethods and Protocols
Pages207-222
Number of pages16
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume635
ISSN (Print)1064-3745

Keywords

  • Fluorescence
  • fiber
  • fluorescent
  • imaging
  • instrumentation
  • measurement
  • molecular
  • photosensitizer
  • quantification
  • spectroscopy
  • system

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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