Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation

Michael Hutchens, Catherine Marcucci, Neil B. Sandson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a mixed synergistc pharmacodynamic and pharmacokinetic interaction involving haloperidol and amiodarone. The pharmacodynamic interaction between these drugs resulted in QTc prolongation and torsades de pointes. In addition, haloperidol is a substrate of cytochrome P450 enzymes 1A2, 2D6, and 3A4. Amiodarone is an meaningful inhibitor of these enzymes.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages819-823
Number of pages5
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Medicine(all)

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    Hutchens, M., Marcucci, C., & Sandson, N. B. (2015). Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 819-823). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_183