Flash Fire

Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation

Michael Hutchens, Catherine Marcucci, Neil B. Sandson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a mixed synergistc pharmacodynamic and pharmacokinetic interaction involving haloperidol and amiodarone. The pharmacodynamic interaction between these drugs resulted in QTc prolongation and torsades de pointes. In addition, haloperidol is a substrate of cytochrome P450 enzymes 1A2, 2D6, and 3A4. Amiodarone is an meaningful inhibitor of these enzymes.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages819-823
Number of pages5
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
DOIs
StatePublished - Sep 15 2015

Fingerprint

Cytochrome P-450 CYP3A
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2D6
Amiodarone
Haloperidol
Torsades de Pointes
Enzyme Inhibitors
Drug Interactions
Cytochrome P-450 Enzyme System
Pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hutchens, M., Marcucci, C., & Sandson, N. B. (2015). Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 819-823). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_183

Flash Fire : Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. / Hutchens, Michael; Marcucci, Catherine; Sandson, Neil B.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 819-823.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hutchens, M, Marcucci, C & Sandson, NB 2015, Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 819-823. https://doi.org/10.1007/978-1-4614-7495-1_183
Hutchens M, Marcucci C, Sandson NB. Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 819-823 https://doi.org/10.1007/978-1-4614-7495-1_183
Hutchens, Michael ; Marcucci, Catherine ; Sandson, Neil B. / Flash Fire : Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 819-823
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