This case discusses a mixed synergistc pharmacodynamic and pharmacokinetic interaction involving haloperidol and amiodarone. The pharmacodynamic interaction between these drugs resulted in QTc prolongation and torsades de pointes. In addition, haloperidol is a substrate of cytochrome P450 enzymes 1A2, 2D6, and 3A4. Amiodarone is an meaningful inhibitor of these enzymes.
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