Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation

Michael P. Hutchens; Catherine Marcucci; Neil B. Sandson

doi:10.1007/978-1-4614-7495-1_183

Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation

Michael P. Hutchens, Catherine Marcucci, Neil B. Sandson

Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses a mixed synergistc pharmacodynamic and pharmacokinetic interaction involving haloperidol and amiodarone. The pharmacodynamic interaction between these drugs resulted in QTc prolongation and torsades de pointes. In addition, haloperidol is a substrate of cytochrome P450 enzymes 1A2, 2D6, and 3A4. Amiodarone is an meaningful inhibitor of these enzymes.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	819-823
Number of pages	5
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_183
State	Published - Sep 15 2015

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7495-1_183

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AB - This case discusses a mixed synergistc pharmacodynamic and pharmacokinetic interaction involving haloperidol and amiodarone. The pharmacodynamic interaction between these drugs resulted in QTc prolongation and torsades de pointes. In addition, haloperidol is a substrate of cytochrome P450 enzymes 1A2, 2D6, and 3A4. Amiodarone is an meaningful inhibitor of these enzymes.

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Flash Fire: Amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6; QT-prolongation

Abstract

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