Flagellar membrane proteins in kinetoplastid parasites

Scott Landfear, Khoa D. Tran, Marco Sanchez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

All kinetoplastid parasites, including protozoa such as Leishmania species, Trypanosoma brucei, and Trypanosoma cruzi that cause devastating diseases in humans and animals, are flagellated throughout their life cycles. Although flagella were originally thought of primarily as motility organelles, flagellar functions in other critical processes, especially in sensing and signal transduction, have become more fully appreciated in the recent past. The flagellar membrane is a highly specialized subdomain of the surface membrane, and flagellar membrane proteins are likely to be critical components for all the biologically important roles of flagella. In this review, we summarize recent discoveries relevant to flagellar membrane proteins in these parasites, including the identification of such proteins, investigation of their biological functions, and mechanisms of selective trafficking to the flagellar membrane. Prospects for future investigations and current unsolved problems are highlighted.

Original languageEnglish (US)
Pages (from-to)668-676
Number of pages9
JournalIUBMB Life
Volume67
Issue number9
DOIs
StatePublished - Sep 1 2015

Fingerprint

Membrane Proteins
Parasites
Flagella
Membranes
Protozoa
Signal transduction
Trypanosoma brucei brucei
Trypanosoma cruzi
Leishmania
Life Cycle Stages
Organelles
Life cycle
Signal Transduction
Animals
Proteins

Keywords

  • channels
  • environmental sensing
  • flagellar membrane
  • kinetoplastid parasites
  • receptors
  • subcellular targeting
  • transporters

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Flagellar membrane proteins in kinetoplastid parasites. / Landfear, Scott; Tran, Khoa D.; Sanchez, Marco.

In: IUBMB Life, Vol. 67, No. 9, 01.09.2015, p. 668-676.

Research output: Contribution to journalArticle

Landfear, Scott ; Tran, Khoa D. ; Sanchez, Marco. / Flagellar membrane proteins in kinetoplastid parasites. In: IUBMB Life. 2015 ; Vol. 67, No. 9. pp. 668-676.
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