First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent

Evidence for human myocardial capillary recruitment in adenosine-induced hyperemia

Xin Li, Charles Jr Springer, Michael Jerosch-Herold

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31 Citations (Scopus)

Abstract

Human myocardial 1H2O T1-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA2-) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (Ktrans) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (τ i) nor its intravascular counterpart (τ b) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the Ktrans evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (PCRS) values. The fact that the PCRS magnitudes almost equal the Ktrans values confirms that GdDTPA2- extravasation in resting human myocardial muscle is indeed permeation-limited and supports the validity of the Ktrans and PCRS estimations. Nevertheless the model analysis is most consistent with the results if PCRS is not assumed to be constant with changing flow. The capillary blood volume fraction (vb) is a sensitive parameter in the analysis. We also compared resting and hyperemic cardiac conditions, the latter resulting from the volume flow increase induced by adenosine arteriolar vasodilation. We found that the PCRS value increases with flow probably mostly because of an S increase associated with capillary recruitment. The vb values also increased in hyperemia and showed a flow-dependence with a clearly identifiable component due to capillary recruitment.

Original languageEnglish (US)
Pages (from-to)148-157
Number of pages10
JournalNMR in Biomedicine
Volume22
Issue number2
DOIs
StatePublished - 2009

Fingerprint

Hyperemia
Adenosine
Magnetic resonance imaging
Water
Rate constants
Kinetics
Pharmacokinetics
Hydraulic conductivity
Gadolinium
Blood Volume
Vasodilation
Permeation
Muscle
Permeability
Volume fraction
Acetates
Blood
Perfusion
Plasmas
Muscles

Keywords

  • Contrast reagent
  • Equilibrium water exchange
  • Flow
  • Myocardial perfusion
  • Permeation

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent: Evidence for human myocardial capillary recruitment in adenosine-induced hyperemia",
abstract = "Human myocardial 1H2O T1-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA2-) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (Ktrans) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (τ i) nor its intravascular counterpart (τ b) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the Ktrans evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (PCRS) values. The fact that the PCRS magnitudes almost equal the Ktrans values confirms that GdDTPA2- extravasation in resting human myocardial muscle is indeed permeation-limited and supports the validity of the Ktrans and PCRS estimations. Nevertheless the model analysis is most consistent with the results if PCRS is not assumed to be constant with changing flow. The capillary blood volume fraction (vb) is a sensitive parameter in the analysis. We also compared resting and hyperemic cardiac conditions, the latter resulting from the volume flow increase induced by adenosine arteriolar vasodilation. We found that the PCRS value increases with flow probably mostly because of an S increase associated with capillary recruitment. The vb values also increased in hyperemia and showed a flow-dependence with a clearly identifiable component due to capillary recruitment.",
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N2 - Human myocardial 1H2O T1-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA2-) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (Ktrans) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (τ i) nor its intravascular counterpart (τ b) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the Ktrans evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (PCRS) values. The fact that the PCRS magnitudes almost equal the Ktrans values confirms that GdDTPA2- extravasation in resting human myocardial muscle is indeed permeation-limited and supports the validity of the Ktrans and PCRS estimations. Nevertheless the model analysis is most consistent with the results if PCRS is not assumed to be constant with changing flow. The capillary blood volume fraction (vb) is a sensitive parameter in the analysis. We also compared resting and hyperemic cardiac conditions, the latter resulting from the volume flow increase induced by adenosine arteriolar vasodilation. We found that the PCRS value increases with flow probably mostly because of an S increase associated with capillary recruitment. The vb values also increased in hyperemia and showed a flow-dependence with a clearly identifiable component due to capillary recruitment.

AB - Human myocardial 1H2O T1-weighted dynamic contrast-enhanced MRI data were acquired during the brief first-pass period after injection of a very small gadolinium diethylenetriaminepenta-acetate (GdDTPA2-) dose. The shutter-speed pharmacokinetic effects of both transendothelial and transcytolemmal equilibrium water exchange processes were investigated. Our results indicate that even for such a short acquisition window and relatively large pseudo-first-order rate constant (Ktrans) for plasma/interstitium contrast reagent (CR) transfer the kinetics of these water exchange processes cannot be treated as infinitely fast or slow. However, neither the intracellular water molecule lifetime (τ i) nor its intravascular counterpart (τ b) are among the parameters most influential in analysis of the noisy data typically associated with the cardiac perfusion application. Thus, the actual values of water exchange kinetic rate constants are relatively indeterminate as this experiment is usually conducted. Combining the Ktrans evaluations with independently determined flow (F) values allows us to estimate CR permeability coefficient surface area product (PCRS) values. The fact that the PCRS magnitudes almost equal the Ktrans values confirms that GdDTPA2- extravasation in resting human myocardial muscle is indeed permeation-limited and supports the validity of the Ktrans and PCRS estimations. Nevertheless the model analysis is most consistent with the results if PCRS is not assumed to be constant with changing flow. The capillary blood volume fraction (vb) is a sensitive parameter in the analysis. We also compared resting and hyperemic cardiac conditions, the latter resulting from the volume flow increase induced by adenosine arteriolar vasodilation. We found that the PCRS value increases with flow probably mostly because of an S increase associated with capillary recruitment. The vb values also increased in hyperemia and showed a flow-dependence with a clearly identifiable component due to capillary recruitment.

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