First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter

Douglas N. Stephens, Uyen T. Truong, Amin Nikoozadeh, Ömer Oralkan, Chi Hyung Seo, Jonathan Cannata, Aaron Dentinger, Kai Thomenius, Alan De La Rama, Tho Nguyen, Feng Lin, Pierre Khuri-Yakub, Aman Mahajan, Kalyanam Shivkumar, Matt O'donnell, David J. Sahn

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objectives: The primary objective was to test in vivo for the first time the general operation of a new multifunctional intracardiac echocardiography (ICE) catheter constructed with a microlinear capacitive micromachined ultrasound transducer (ML-CMUT) imaging array. Secondarily, we examined the compatibility of this catheter with electroanatomic mapping (EAM) guidance and also as a radiofrequency ablation (RFA) catheter. Preliminary thermal strain imaging (TSI)-derived temperature data were obtained from within the endocardium simultaneously during RFA to show the feasibility of direct ablation guidance procedures. Methods: The new 9F forward-looking ICE catheter was constructed with 3 complementary technologies: a CMUT imaging array with a custom electronic array buffer, catheter surface electrodes for EAM guidance, and a special ablation tip, that permits simultaneous TSI and RFA In vivo imaging studies of 5 anesthetized porcine models with 5 CMUT catheters were performed. Results: The ML-CMUT ICE catheter provided high-resolution real-time wideband 2-dimensional (2D) images at greater than 8 MHz and is capable of both RFA and EAM guidance. Although the 24-element array aperture dimension is only 1.5 mm, the imaging depth of penetration is greater than 30 mm. The specially designed ultrasoundcompatible metalized plastic tip allowed simultaneous imaging during ablation and direct acquisition of TSI data for tissue ablation temperatures. Postprocessing analysis showed a first-order correlation between TSI and temperature, permitting early development temperature-time relationships at specific myocardial ablation sites. Conclusions: Multifunctional forward-looking ML-CMUT ICE catheters, with simultaneous intracardiac guidance, ultrasound imaging, and RFA, may offer a new means to improve interventional ablation procedures.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalJournal of Ultrasound in Medicine
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Ablation
  • Capacitive micromachined ultrasound transducer
  • Electro - anatomic mapping
  • Electrophysiology
  • Intracardiac echocardiography
  • Intracardiac imaging
  • Microelectromechanical system
  • Thermal strain

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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