First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter

Douglas N. Stephens, Uyen T. Truong, Amin Nikoozadeh, Ömer Oralkan, Chi Hyung Seo, Jonathan Cannata, Aaron Dentinger, Kai Thomenius, Alan De La Rama, Tho Nguyen, Feng Lin, Pierre Khuri-Yakub, Aman Mahajan, Kalyanam Shivkumar, Matt O'donnell, David Sahn

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives: The primary objective was to test in vivo for the first time the general operation of a new multifunctional intracardiac echocardiography (ICE) catheter constructed with a microlinear capacitive micromachined ultrasound transducer (ML-CMUT) imaging array. Secondarily, we examined the compatibility of this catheter with electroanatomic mapping (EAM) guidance and also as a radiofrequency ablation (RFA) catheter. Preliminary thermal strain imaging (TSI)-derived temperature data were obtained from within the endocardium simultaneously during RFA to show the feasibility of direct ablation guidance procedures. Methods: The new 9F forward-looking ICE catheter was constructed with 3 complementary technologies: a CMUT imaging array with a custom electronic array buffer, catheter surface electrodes for EAM guidance, and a special ablation tip, that permits simultaneous TSI and RFA In vivo imaging studies of 5 anesthetized porcine models with 5 CMUT catheters were performed. Results: The ML-CMUT ICE catheter provided high-resolution real-time wideband 2-dimensional (2D) images at greater than 8 MHz and is capable of both RFA and EAM guidance. Although the 24-element array aperture dimension is only 1.5 mm, the imaging depth of penetration is greater than 30 mm. The specially designed ultrasoundcompatible metalized plastic tip allowed simultaneous imaging during ablation and direct acquisition of TSI data for tissue ablation temperatures. Postprocessing analysis showed a first-order correlation between TSI and temperature, permitting early development temperature-time relationships at specific myocardial ablation sites. Conclusions: Multifunctional forward-looking ML-CMUT ICE catheters, with simultaneous intracardiac guidance, ultrasound imaging, and RFA, may offer a new means to improve interventional ablation procedures.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalJournal of Ultrasound in Medicine
Volume31
Issue number2
StatePublished - Feb 1 2012

Fingerprint

Cardiac Catheters
Catheter Ablation
Transducers
Echocardiography
Hot Temperature
Temperature
Catheters
Ultrasonography
Endocardium
Plastics
Buffers
Electrodes
Swine
Technology

Keywords

  • Ablation
  • Capacitive micromachined ultrasound transducer
  • Electro - anatomic mapping
  • Electrophysiology
  • Intracardiac echocardiography
  • Intracardiac imaging
  • Microelectromechanical system
  • Thermal strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Stephens, D. N., Truong, U. T., Nikoozadeh, A., Oralkan, Ö., Seo, C. H., Cannata, J., ... Sahn, D. (2012). First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter. Journal of Ultrasound in Medicine, 31(2), 247-256.

First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter. / Stephens, Douglas N.; Truong, Uyen T.; Nikoozadeh, Amin; Oralkan, Ömer; Seo, Chi Hyung; Cannata, Jonathan; Dentinger, Aaron; Thomenius, Kai; De La Rama, Alan; Nguyen, Tho; Lin, Feng; Khuri-Yakub, Pierre; Mahajan, Aman; Shivkumar, Kalyanam; O'donnell, Matt; Sahn, David.

In: Journal of Ultrasound in Medicine, Vol. 31, No. 2, 01.02.2012, p. 247-256.

Research output: Contribution to journalArticle

Stephens, DN, Truong, UT, Nikoozadeh, A, Oralkan, Ö, Seo, CH, Cannata, J, Dentinger, A, Thomenius, K, De La Rama, A, Nguyen, T, Lin, F, Khuri-Yakub, P, Mahajan, A, Shivkumar, K, O'donnell, M & Sahn, D 2012, 'First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter', Journal of Ultrasound in Medicine, vol. 31, no. 2, pp. 247-256.
Stephens DN, Truong UT, Nikoozadeh A, Oralkan Ö, Seo CH, Cannata J et al. First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter. Journal of Ultrasound in Medicine. 2012 Feb 1;31(2):247-256.
Stephens, Douglas N. ; Truong, Uyen T. ; Nikoozadeh, Amin ; Oralkan, Ömer ; Seo, Chi Hyung ; Cannata, Jonathan ; Dentinger, Aaron ; Thomenius, Kai ; De La Rama, Alan ; Nguyen, Tho ; Lin, Feng ; Khuri-Yakub, Pierre ; Mahajan, Aman ; Shivkumar, Kalyanam ; O'donnell, Matt ; Sahn, David. / First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter. In: Journal of Ultrasound in Medicine. 2012 ; Vol. 31, No. 2. pp. 247-256.
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AU - Stephens, Douglas N.

AU - Truong, Uyen T.

AU - Nikoozadeh, Amin

AU - Oralkan, Ömer

AU - Seo, Chi Hyung

AU - Cannata, Jonathan

AU - Dentinger, Aaron

AU - Thomenius, Kai

AU - De La Rama, Alan

AU - Nguyen, Tho

AU - Lin, Feng

AU - Khuri-Yakub, Pierre

AU - Mahajan, Aman

AU - Shivkumar, Kalyanam

AU - O'donnell, Matt

AU - Sahn, David

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