First-degree relatives of patients with advanced colorectal adenomas have an increased prevalence of colorectal cancer

Kathryn L. Lynch, Dennis J. Ahnen, Tim Byers, David G. Weiss, David Lieberman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background & Aims: The risk of colorectal cancer in relatives of patients with adenomatous colonic polyps is not well defined. This study assessed whether finding colonic neoplasia during screening colonoscopy was related to the family history of colorectal cancer among the participants' parents and siblings. Methods: Self-reported family history of colorectal cancer was recorded for all participants in a screening colonoscopy study. The size and location of all polyps were recorded before their removal and histologic examination. Participants were grouped according to the most advanced lesion detected. Results: Three thousand one hundred twenty-one patients underwent complete colonoscopic examination. Subjects with adenomas were more likely to have a family history of colorectal cancer than were subjects without polyps (odds ratio [OR], 1.36; 95% confidence interval [Cl], 1.09-1.70). The finding of a small (

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalClinical Gastroenterology and Hepatology
Volume1
Issue number2
DOIs
StatePublished - Mar 1 2003

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Adenoma
Colorectal Neoplasms
Colonoscopy
Polyps
Colonic Polyps
Adenomatous Polyps
Siblings
Parents
Odds Ratio
Confidence Intervals
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

First-degree relatives of patients with advanced colorectal adenomas have an increased prevalence of colorectal cancer. / Lynch, Kathryn L.; Ahnen, Dennis J.; Byers, Tim; Weiss, David G.; Lieberman, David.

In: Clinical Gastroenterology and Hepatology, Vol. 1, No. 2, 01.03.2003, p. 96-102.

Research output: Contribution to journalArticle

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