Fine-needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis

Melinda M. Racz, Rodney Pommier, Megan Troxell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Medullary carcinoma is a rare variant of breast carcinoma with a relatively good clinical prognosis as strictly defined. Characteristic features on fine-needle aspiration cytology (FNAC) allow medullary carcinoma to be considered in the cytologic differential diagnosis. We present two FNAC cases with such features, including high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background, and illustrate one case in liquid-based preparation. Surgical excision revealed that one patient had medullary carcinoma, while the second patient had high-grade infiltrating ductal carcinoma. Breast FNAC samples with syncytial fragments, bizarre nuclei with prominent nucleoli, and a chronic inflammatory infiltrate should raise the possibility of medullary carcinoma. However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalDiagnostic Cytopathology
Volume35
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Medullary Carcinoma
Fine Needle Biopsy
Cell Biology
Differential Diagnosis
Breast Neoplasms
Ductal Carcinoma
Breast
Lymphoma
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Breast carcinoma
  • Fine-needle aspiration cytology (FNAC)
  • Liquid-based preparation (LBP)
  • Medullary carcinoma

ASJC Scopus subject areas

  • Anatomy

Cite this

Fine-needle aspiration cytology of medullary breast carcinoma : Report of two cases and review of the literature with emphasis on differential diagnosis. / Racz, Melinda M.; Pommier, Rodney; Troxell, Megan.

In: Diagnostic Cytopathology, Vol. 35, No. 6, 06.2007, p. 313-318.

Research output: Contribution to journalArticle

@article{7c73ed16cbeb4fc1b1693f5d2c4b499c,
title = "Fine-needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis",
abstract = "Medullary carcinoma is a rare variant of breast carcinoma with a relatively good clinical prognosis as strictly defined. Characteristic features on fine-needle aspiration cytology (FNAC) allow medullary carcinoma to be considered in the cytologic differential diagnosis. We present two FNAC cases with such features, including high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background, and illustrate one case in liquid-based preparation. Surgical excision revealed that one patient had medullary carcinoma, while the second patient had high-grade infiltrating ductal carcinoma. Breast FNAC samples with syncytial fragments, bizarre nuclei with prominent nucleoli, and a chronic inflammatory infiltrate should raise the possibility of medullary carcinoma. However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis.",
keywords = "Breast carcinoma, Fine-needle aspiration cytology (FNAC), Liquid-based preparation (LBP), Medullary carcinoma",
author = "Racz, {Melinda M.} and Rodney Pommier and Megan Troxell",
year = "2007",
month = "6",
doi = "10.1002/dc.20639",
language = "English (US)",
volume = "35",
pages = "313--318",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Fine-needle aspiration cytology of medullary breast carcinoma

T2 - Report of two cases and review of the literature with emphasis on differential diagnosis

AU - Racz, Melinda M.

AU - Pommier, Rodney

AU - Troxell, Megan

PY - 2007/6

Y1 - 2007/6

N2 - Medullary carcinoma is a rare variant of breast carcinoma with a relatively good clinical prognosis as strictly defined. Characteristic features on fine-needle aspiration cytology (FNAC) allow medullary carcinoma to be considered in the cytologic differential diagnosis. We present two FNAC cases with such features, including high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background, and illustrate one case in liquid-based preparation. Surgical excision revealed that one patient had medullary carcinoma, while the second patient had high-grade infiltrating ductal carcinoma. Breast FNAC samples with syncytial fragments, bizarre nuclei with prominent nucleoli, and a chronic inflammatory infiltrate should raise the possibility of medullary carcinoma. However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis.

AB - Medullary carcinoma is a rare variant of breast carcinoma with a relatively good clinical prognosis as strictly defined. Characteristic features on fine-needle aspiration cytology (FNAC) allow medullary carcinoma to be considered in the cytologic differential diagnosis. We present two FNAC cases with such features, including high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background, and illustrate one case in liquid-based preparation. Surgical excision revealed that one patient had medullary carcinoma, while the second patient had high-grade infiltrating ductal carcinoma. Breast FNAC samples with syncytial fragments, bizarre nuclei with prominent nucleoli, and a chronic inflammatory infiltrate should raise the possibility of medullary carcinoma. However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis.

KW - Breast carcinoma

KW - Fine-needle aspiration cytology (FNAC)

KW - Liquid-based preparation (LBP)

KW - Medullary carcinoma

UR - http://www.scopus.com/inward/record.url?scp=34249743128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249743128&partnerID=8YFLogxK

U2 - 10.1002/dc.20639

DO - 10.1002/dc.20639

M3 - Article

C2 - 17497662

AN - SCOPUS:34249743128

VL - 35

SP - 313

EP - 318

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 6

ER -