Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus

J. W. Gnann, Jay Nelson, M. B A Oldstone

Research output: Contribution to journalArticle

178 Scopus citations


Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

Original languageEnglish (US)
Pages (from-to)2639-2641
Number of pages3
JournalJournal of Virology
Issue number8
Publication statusPublished - 1987
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

Cite this