TY - JOUR
T1 - Finding the relevance of antimicrobial stewardship for cystic fibrosis
AU - Antimicrobial Resistance International Working Group in Cystic Fibrosis
AU - Cogen, Jonathan D.
AU - Kahl, Barbara C.
AU - Maples, Holly
AU - McColley, Susanna A.
AU - Roberts, Jason A.
AU - Winthrop, Kevin L.
AU - Morris, Andrew M.
AU - Holmes, Alison
AU - Flume, Patrick A.
AU - VanDevanter, Donald R.
AU - Waters, Valerie
AU - Muhlebach, Marianne S.
AU - Elborn, J. Stuart
AU - Saiman, Lisa
AU - Bell, Scott C.
N1 - Publisher Copyright:
© 2020
PY - 2020/7
Y1 - 2020/7
N2 - Antimicrobials have undoubtedly improved the lives of people with CF, but important antimicrobial-related toxicities and the emergence of antimicrobial-resistant bacteria associated with their use must be considered. Antimicrobial stewardship (AMS) is advocated across the spectrum of healthcare to promote the appropriate use of antimicrobials to preserve their current effectiveness and to optimise treatment, and it is clear that AMS strategies are applicable to and can benefit both non-CF and CF populations. This perspective explores the definition and components of an AMS program, the current evidence for AMS, and the reasons why AMS is a challenging concept in the provision of CF care. We also discuss the elements of CF care which align with AMS programs and principles and propose research priorities for AMS in CF.
AB - Antimicrobials have undoubtedly improved the lives of people with CF, but important antimicrobial-related toxicities and the emergence of antimicrobial-resistant bacteria associated with their use must be considered. Antimicrobial stewardship (AMS) is advocated across the spectrum of healthcare to promote the appropriate use of antimicrobials to preserve their current effectiveness and to optimise treatment, and it is clear that AMS strategies are applicable to and can benefit both non-CF and CF populations. This perspective explores the definition and components of an AMS program, the current evidence for AMS, and the reasons why AMS is a challenging concept in the provision of CF care. We also discuss the elements of CF care which align with AMS programs and principles and propose research priorities for AMS in CF.
KW - Antimicrobial stewardship
KW - Antimicrobials
KW - Pulmonary Exacerbations
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U2 - 10.1016/j.jcf.2020.02.012
DO - 10.1016/j.jcf.2020.02.012
M3 - Review article
C2 - 32122785
AN - SCOPUS:85080131977
SN - 1569-1993
VL - 19
SP - 511
EP - 520
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 4
ER -