TY - JOUR
T1 - Final words
T2 - Cell age and cell cycle are unlinked
AU - Spellman, Paul T.
AU - Sherlock, Gavin
PY - 2004/6
Y1 - 2004/6
N2 - Cooper has a simple belief: that the cell cycle is connected to age and size. Furthermore, as a result of this connection in his mind he believes that there are no possible manipulations that can operate on a batch culture to synchronize cells within the cell cycle, such that those cells can undergo a semblance of a normal cell cycle. His formulation of this argument is as a 'fundamental law', the law of conservation of cell-age order (LCCAO). The first part of this law - 'there is no batch treatment of the culture that can lead to an alteration of the cell-age order' - can probably be proved true, in the mathematical sense, and certainly makes intuitive sense. Unfortunately the corollaries of this law are rather suspect, drawing inferences from cell age to cell size to the cell cycle.
AB - Cooper has a simple belief: that the cell cycle is connected to age and size. Furthermore, as a result of this connection in his mind he believes that there are no possible manipulations that can operate on a batch culture to synchronize cells within the cell cycle, such that those cells can undergo a semblance of a normal cell cycle. His formulation of this argument is as a 'fundamental law', the law of conservation of cell-age order (LCCAO). The first part of this law - 'there is no batch treatment of the culture that can lead to an alteration of the cell-age order' - can probably be proved true, in the mathematical sense, and certainly makes intuitive sense. Unfortunately the corollaries of this law are rather suspect, drawing inferences from cell age to cell size to the cell cycle.
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U2 - 10.1016/j.tibtech.2004.04.012
DO - 10.1016/j.tibtech.2004.04.012
M3 - Article
C2 - 15158055
AN - SCOPUS:2442611894
SN - 0167-7799
VL - 22
SP - 277
EP - 278
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 6
ER -