TY - JOUR
T1 - Fimbrial adhesins of Salmonella typhimurium
T2 - Role in bacterial interactions with epithelial cells
AU - Bäumler, A. J.
AU - Tsolis, R. M.
AU - Heffron, F.
PY - 1997
Y1 - 1997
N2 - S. typhimurium initiates infection of its mammalian host by attachment to mucosal surfaces in the intestine and subsequent invasion of epithelial cells. To date, three S. typhimurium fimbrial operons, fim, lpf and pef, have been characterized. This analysis suggests that fimbrial adhesins fulfill multiple functions during the initial phase of an infection. In addition to their role in colonization of the small intestine, adhesins contribute to the tissue tropism for Peyer's patches, which is characteristic for Salmonella infections. Furthermore, by mediating the initial contact to epithelial cells, fimbrial adhesins appear to be necessary for invasion and possibly for elicitation of an inflammatory response. Thus, fimbriae are important virulence factors of S. typhimurium and their future analysis promises to yield fascinating new insights into host-parasite interactions of this pathogen.
AB - S. typhimurium initiates infection of its mammalian host by attachment to mucosal surfaces in the intestine and subsequent invasion of epithelial cells. To date, three S. typhimurium fimbrial operons, fim, lpf and pef, have been characterized. This analysis suggests that fimbrial adhesins fulfill multiple functions during the initial phase of an infection. In addition to their role in colonization of the small intestine, adhesins contribute to the tissue tropism for Peyer's patches, which is characteristic for Salmonella infections. Furthermore, by mediating the initial contact to epithelial cells, fimbrial adhesins appear to be necessary for invasion and possibly for elicitation of an inflammatory response. Thus, fimbriae are important virulence factors of S. typhimurium and their future analysis promises to yield fascinating new insights into host-parasite interactions of this pathogen.
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U2 - 10.1007/978-1-4899-1828-4_23
DO - 10.1007/978-1-4899-1828-4_23
M3 - Article
C2 - 9192007
AN - SCOPUS:0030958936
SN - 0065-2598
VL - 412
SP - 149
EP - 158
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -