Filtration of water from mother to conceptus via paths independent of fetal placental circulation in sheep

Debra Anderson, N. J P Borst, R. D H Boyd, J. J. Faber

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    1. Four pregnant ewes were operated on at 121-126 days of gestation. An electromagnetic flow sensor and an inflatable occluder were placed on the maternal common internal iliac artery. The ovarian arteries and veins were ligated. Indwelling catheters were placed in a maternal femoral artery and uterine vein and in the amniotic and allantoic fluids. An inflatable occluder was placed around the umbilical cord, close to the fetal abdomen. 2. Eight to nine days aftr surgery, the cord was occluded, the fetus killed and uterine blood flow reduced to one-quarter of its control value. The rate of water loss from the uterine circulation was calculated from blood flow and the venoarterial difference in blood osmolality. The amniotic and allantoic fluids were made hypertonic by infusion of 2 l into each sac of a solution of 1.5 mol of mannitol per litre of saline. The rate of water loss from the maternal uterine circulation was then measured five times over the next 4.5 h. 3. The combined filtration coefficient surface area product of the interfaces between maternal blood and the amniotic and allantoic sacs, normalized per kilogram fetal body weight, was (2.8±0.5) x 10-6 cm3 s-1 kPa-1 kg-1 (mean±S.E.M.).

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalJournal of Physiology
    Volume431
    StatePublished - 1990

    Fingerprint

    Placental Circulation
    Sheep
    Mothers
    Water
    Amniotic Fluid
    Veins
    Fetal Weight
    Indwelling Catheters
    Iliac Artery
    Umbilical Cord
    Electromagnetic Phenomena
    Mannitol
    Femoral Artery
    Ambulatory Surgical Procedures
    Abdomen
    Osmolar Concentration
    Fetus
    Arteries
    Pregnancy

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Anderson, D., Borst, N. J. P., Boyd, R. D. H., & Faber, J. J. (1990). Filtration of water from mother to conceptus via paths independent of fetal placental circulation in sheep. Journal of Physiology, 431, 1-10.

    Filtration of water from mother to conceptus via paths independent of fetal placental circulation in sheep. / Anderson, Debra; Borst, N. J P; Boyd, R. D H; Faber, J. J.

    In: Journal of Physiology, Vol. 431, 1990, p. 1-10.

    Research output: Contribution to journalArticle

    Anderson, Debra ; Borst, N. J P ; Boyd, R. D H ; Faber, J. J. / Filtration of water from mother to conceptus via paths independent of fetal placental circulation in sheep. In: Journal of Physiology. 1990 ; Vol. 431. pp. 1-10.
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    N2 - 1. Four pregnant ewes were operated on at 121-126 days of gestation. An electromagnetic flow sensor and an inflatable occluder were placed on the maternal common internal iliac artery. The ovarian arteries and veins were ligated. Indwelling catheters were placed in a maternal femoral artery and uterine vein and in the amniotic and allantoic fluids. An inflatable occluder was placed around the umbilical cord, close to the fetal abdomen. 2. Eight to nine days aftr surgery, the cord was occluded, the fetus killed and uterine blood flow reduced to one-quarter of its control value. The rate of water loss from the uterine circulation was calculated from blood flow and the venoarterial difference in blood osmolality. The amniotic and allantoic fluids were made hypertonic by infusion of 2 l into each sac of a solution of 1.5 mol of mannitol per litre of saline. The rate of water loss from the maternal uterine circulation was then measured five times over the next 4.5 h. 3. The combined filtration coefficient surface area product of the interfaces between maternal blood and the amniotic and allantoic sacs, normalized per kilogram fetal body weight, was (2.8±0.5) x 10-6 cm3 s-1 kPa-1 kg-1 (mean±S.E.M.).

    AB - 1. Four pregnant ewes were operated on at 121-126 days of gestation. An electromagnetic flow sensor and an inflatable occluder were placed on the maternal common internal iliac artery. The ovarian arteries and veins were ligated. Indwelling catheters were placed in a maternal femoral artery and uterine vein and in the amniotic and allantoic fluids. An inflatable occluder was placed around the umbilical cord, close to the fetal abdomen. 2. Eight to nine days aftr surgery, the cord was occluded, the fetus killed and uterine blood flow reduced to one-quarter of its control value. The rate of water loss from the uterine circulation was calculated from blood flow and the venoarterial difference in blood osmolality. The amniotic and allantoic fluids were made hypertonic by infusion of 2 l into each sac of a solution of 1.5 mol of mannitol per litre of saline. The rate of water loss from the maternal uterine circulation was then measured five times over the next 4.5 h. 3. The combined filtration coefficient surface area product of the interfaces between maternal blood and the amniotic and allantoic sacs, normalized per kilogram fetal body weight, was (2.8±0.5) x 10-6 cm3 s-1 kPa-1 kg-1 (mean±S.E.M.).

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