Fibrosis, gene expression and orbital inflammatory disease

James (Jim) Rosenbaum, Dongseok Choi, David Wilson, Hans E. Grossniklaus, Christina (Chris) Harrington, Roger Dailey, John Ng, Eric Steele, Craig N. Czyz, Jill A. Foster, David Tse, Chris Alabiad, Sander Dubovy, Prashant Parekh, Gerald J. Harris, Michael Kazim, Payal Patel, Valerie White, Peter Dolman, Deepak P. EdwardHind Alkatan, Hailahal Hussain, Dinesh Selva, Patrick Yeatts, Bobby Korn, Don Kikkawa, Patrick Stauffer, Stephen Planck

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: To clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our Results: with those reported for idiopathic pulmonary fibrosis. Methods: We collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray. Results: Within orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis ( p

Original languageEnglish (US)
Pages (from-to)1424-1429
Number of pages6
JournalBritish Journal of Ophthalmology
Volume99
Issue number10
DOIs
StatePublished - Oct 1 2015

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Orbital Diseases
Granulomatosis with Polyangiitis
Fibrosis
Sarcoidosis
Gene Expression
Fats
Inflammation
Biopsy
Lacrimal Apparatus
Idiopathic Pulmonary Fibrosis
Eye Diseases
Thyroid Diseases

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Fibrosis, gene expression and orbital inflammatory disease. / Rosenbaum, James (Jim); Choi, Dongseok; Wilson, David; Grossniklaus, Hans E.; Harrington, Christina (Chris); Dailey, Roger; Ng, John; Steele, Eric; Czyz, Craig N.; Foster, Jill A.; Tse, David; Alabiad, Chris; Dubovy, Sander; Parekh, Prashant; Harris, Gerald J.; Kazim, Michael; Patel, Payal; White, Valerie; Dolman, Peter; Edward, Deepak P.; Alkatan, Hind; Hussain, Hailahal; Selva, Dinesh; Yeatts, Patrick; Korn, Bobby; Kikkawa, Don; Stauffer, Patrick; Planck, Stephen.

In: British Journal of Ophthalmology, Vol. 99, No. 10, 01.10.2015, p. 1424-1429.

Research output: Contribution to journalArticle

Rosenbaum, JJ, Choi, D, Wilson, D, Grossniklaus, HE, Harrington, CC, Dailey, R, Ng, J, Steele, E, Czyz, CN, Foster, JA, Tse, D, Alabiad, C, Dubovy, S, Parekh, P, Harris, GJ, Kazim, M, Patel, P, White, V, Dolman, P, Edward, DP, Alkatan, H, Hussain, H, Selva, D, Yeatts, P, Korn, B, Kikkawa, D, Stauffer, P & Planck, S 2015, 'Fibrosis, gene expression and orbital inflammatory disease', British Journal of Ophthalmology, vol. 99, no. 10, pp. 1424-1429. https://doi.org/10.1136/bjophthalmol-2015-306614
Rosenbaum, James (Jim) ; Choi, Dongseok ; Wilson, David ; Grossniklaus, Hans E. ; Harrington, Christina (Chris) ; Dailey, Roger ; Ng, John ; Steele, Eric ; Czyz, Craig N. ; Foster, Jill A. ; Tse, David ; Alabiad, Chris ; Dubovy, Sander ; Parekh, Prashant ; Harris, Gerald J. ; Kazim, Michael ; Patel, Payal ; White, Valerie ; Dolman, Peter ; Edward, Deepak P. ; Alkatan, Hind ; Hussain, Hailahal ; Selva, Dinesh ; Yeatts, Patrick ; Korn, Bobby ; Kikkawa, Don ; Stauffer, Patrick ; Planck, Stephen. / Fibrosis, gene expression and orbital inflammatory disease. In: British Journal of Ophthalmology. 2015 ; Vol. 99, No. 10. pp. 1424-1429.
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AU - Ng, John

AU - Steele, Eric

AU - Czyz, Craig N.

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AU - Dolman, Peter

AU - Edward, Deepak P.

AU - Alkatan, Hind

AU - Hussain, Hailahal

AU - Selva, Dinesh

AU - Yeatts, Patrick

AU - Korn, Bobby

AU - Kikkawa, Don

AU - Stauffer, Patrick

AU - Planck, Stephen

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