Fibromyalgia

Harmonizing science with clinical practice considerations

Serge Perrot, Anthony H. Dickenson, Robert (Rob) Bennett

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    This review summarizes the present and emerging knowledge base on the pathophysiology, diagnosis, and management of fibromyalgia. Epidemiology: Fibromyalgia is the most common chronic pain syndrome encountered in general medicine and rheumatology. Historically, contemporary concepts of fibromyalgia have evolved in terms of its clinical description and parallel advances in the understanding of its pathophysiology. Pathophysiology: A generally accepted paradigm postulates that fibromyalgia is the clinical expression of a rheumatologic disorder in which the associated pain is driven primarily by central sensitization and possibly through changes in several neuronal systems but not necessarily reliant on peripheral processes. Management: Several agents, including serotonin-norepinephrine reuptake inhibitors (ie, duloxetine and milnacipran), opioids (ie, tramadol), and the α2-δ ligand pregabalin, which recently received U.S. regulatory approval for the treatment of fibromyalgia, have been evaluated in clinical trials, demonstrating benefit in terms of pain reduction and improvement in core symptoms (ie, fatigue and sleep disturbance). The European League Against Rheumatism has developed updated guidelines for the management of fibromyalgia.

    Original languageEnglish (US)
    Pages (from-to)177-189
    Number of pages13
    JournalPain Practice
    Volume8
    Issue number3
    DOIs
    StatePublished - May 2008

    Fingerprint

    Fibromyalgia
    Central Nervous System Sensitization
    Pain
    Tramadol
    Knowledge Bases
    Rheumatology
    Chronic Pain
    Opioid Analgesics
    Fatigue
    Sleep
    Epidemiology
    Medicine
    Clinical Trials
    Guidelines
    Ligands

    Keywords

    • Central nervous system
    • Central sensitization
    • Fibromyalgia

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine

    Cite this

    Fibromyalgia : Harmonizing science with clinical practice considerations. / Perrot, Serge; Dickenson, Anthony H.; Bennett, Robert (Rob).

    In: Pain Practice, Vol. 8, No. 3, 05.2008, p. 177-189.

    Research output: Contribution to journalArticle

    Perrot, Serge ; Dickenson, Anthony H. ; Bennett, Robert (Rob). / Fibromyalgia : Harmonizing science with clinical practice considerations. In: Pain Practice. 2008 ; Vol. 8, No. 3. pp. 177-189.
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