Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men

Richard Marsell, Elin Grundberg, Tijana Krajisnik, Hans Mallmin, Magnus Karlsson, Dan Mellström, Eric Orwoll, Claes Ohlsson, Kenneth B. Jonsson, Östen Ljunggren, Tobias E. Larsson

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of the current study was to determine the relationship between FGF23, PTH, and other biochemistries in vivo in subjects with no history of renal disease. Design: Serum biochemistries were measured in a subsample of the population-based Swedishpart of the MrOS study. In total, 1000 Caucasian men aged 70-80 years were randomly selected from the population. Methods: Intact FGF23, Pi, calcium, albumin, estimated glomerular filtration rate (eGFR, calculated from cystatin C), PTH, and 25(OH)D3 were measured. Association studies were performed using linear univariate and multivariate regression analyses. Results: The median FGF23 level was 36.6 pg/ml, ranging from 0.63 to 957 pg/ml. There was a significant correlation between log FGF23 and eGFR (r= -0.21; P60 ml/min. Only eGFR (β= -0.35; P

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalEuropean Journal of Endocrinology
Volume158
Issue number1
DOIs
StatePublished - Jan 2008

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Parathyroid Hormone
Kidney
Population
Biochemistry
Hyperphosphatemia
Cystatin C
Factor V
fibroblast growth factor 23
Serum
Glomerular Filtration Rate
Chronic Renal Insufficiency
Vitamin D
Albumins
Multivariate Analysis
Phosphates
Regression Analysis
Calcium

ASJC Scopus subject areas

  • Endocrinology

Cite this

Marsell, R., Grundberg, E., Krajisnik, T., Mallmin, H., Karlsson, M., Mellström, D., ... Larsson, T. E. (2008). Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men. European Journal of Endocrinology, 158(1), 125-129. https://doi.org/10.1530/EJE-07-0534

Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men. / Marsell, Richard; Grundberg, Elin; Krajisnik, Tijana; Mallmin, Hans; Karlsson, Magnus; Mellström, Dan; Orwoll, Eric; Ohlsson, Claes; Jonsson, Kenneth B.; Ljunggren, Östen; Larsson, Tobias E.

In: European Journal of Endocrinology, Vol. 158, No. 1, 01.2008, p. 125-129.

Research output: Contribution to journalArticle

Marsell, R, Grundberg, E, Krajisnik, T, Mallmin, H, Karlsson, M, Mellström, D, Orwoll, E, Ohlsson, C, Jonsson, KB, Ljunggren, Ö & Larsson, TE 2008, 'Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men', European Journal of Endocrinology, vol. 158, no. 1, pp. 125-129. https://doi.org/10.1530/EJE-07-0534
Marsell, Richard ; Grundberg, Elin ; Krajisnik, Tijana ; Mallmin, Hans ; Karlsson, Magnus ; Mellström, Dan ; Orwoll, Eric ; Ohlsson, Claes ; Jonsson, Kenneth B. ; Ljunggren, Östen ; Larsson, Tobias E. / Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men. In: European Journal of Endocrinology. 2008 ; Vol. 158, No. 1. pp. 125-129.
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AU - Orwoll, Eric

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