Fibrinogen: Structure, function, and surface interactions

Cristina Fuss, J. C. Palmaz, E. A. Sprague

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α1163 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume12
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Fibrinogen
Blood Vessels
Blood Platelets
Platelet Glycoprotein GPIIb-IIIa Complex
Molecular Structure
Integrins
Polymerization
Thrombosis
Pharmaceutical Preparations
Therapeutics

Keywords

  • Anticoagulant
  • Fibrinogen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fibrinogen : Structure, function, and surface interactions. / Fuss, Cristina; Palmaz, J. C.; Sprague, E. A.

In: Journal of Vascular and Interventional Radiology, Vol. 12, No. 6, 2001, p. 677-682.

Research output: Contribution to journalArticle

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