Fibrinogen: Structure, function, and surface interactions

C. Fuss, J. C. Palmaz, E. A. Sprague

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α1163 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Anticoagulant
  • Fibrinogen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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