Fibrillin-1 in incisional hernias

An immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae

Martin Fricke, Claus Langer, Edgar Brunner, Lynn Sakai, Laszlo Füzesi, Dieter P. Reinhardt, Fabio Quondamatteo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Incisional hernias represent one of the most common complications after laparotomy. Specific pre-operative risk factors have not yet been identified. Recent studies indicate that changes in extracellular matrix components such as collagen I and collagen III may be involved in hernia development. In the present study we have evaluated the significance of fibrillin-1 in hernia development as one of the main components of the extracellular matrix. Tissue samples from non-scar skin and muscle fascia of 12 patients with incisional hernias as well as from the respective scar tissues were obtained. Corresponding tissue samples of 10 patients with normal postoperative wound healing served as controls. Distribution of fibrillin-1 was evaluated immunohistochemically. Differences in fibrillin-1 distribution in the non-scar tissues of muscle fascia have been found in patients with incisional hernia, compared to those without hernia. In scar regions of both patient groups, slight differences in the pattern of fibrillin-1 were observed. A tendency to a differential deposition of fibrillin-1 in skin samples, although hardly quantifiable, was observed as well. Our results suggest that fibrillin-1 is a relevant factor contributing to tissue stability. Disturbances in its deposition, even before scar formation, may be an important factor to the development of incisional hernias.

Original languageEnglish (US)
Pages (from-to)674-685
Number of pages12
JournalJournal of Anatomy
Volume212
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

fascia
hernia
Fascia
skin (animal)
Cicatrix
skin
muscle
Muscles
muscles
Skin
Hernia
collagen
Extracellular Matrix
extracellular matrix
Collagen
matrix
risk factor
laparotomy
Wound Healing
Laparotomy

Keywords

  • Extra cellular matrix
  • Fibrillin-1
  • Incisional hernias
  • Muscle fascia
  • Scar
  • Skin

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Fibrillin-1 in incisional hernias : An immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae. / Fricke, Martin; Langer, Claus; Brunner, Edgar; Sakai, Lynn; Füzesi, Laszlo; Reinhardt, Dieter P.; Quondamatteo, Fabio.

In: Journal of Anatomy, Vol. 212, No. 5, 01.05.2008, p. 674-685.

Research output: Contribution to journalArticle

Fricke, Martin ; Langer, Claus ; Brunner, Edgar ; Sakai, Lynn ; Füzesi, Laszlo ; Reinhardt, Dieter P. ; Quondamatteo, Fabio. / Fibrillin-1 in incisional hernias : An immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae. In: Journal of Anatomy. 2008 ; Vol. 212, No. 5. pp. 674-685.
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