Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

Agriculture & Biology

• mutation 62%
• mice 52%
• genome 50%
• fibroblasts 45%
• carcinogens 41%
• embryo (animal) 36%
• kidney cells 27%
• DNA 19%
• kidneys 18%
• alleles 17%
• sequence deletion 17%
• genomics 16%
• anthracenes 16%
• caspase-3 15%
• point mutation 14%
• cells 12%
• apoptosis 11%
• tissue culture 11%
• cell proliferation 11%
• lesions (animal) 10%
• phenotype 8%
• chromosomes 8%
• liver 7%
• tissues 5%
• genes 4%

Medicine & Life Sciences

• Genomic Instability 100%
• Mutation 51%
• Exome 46%
• Embryonic Structures 42%
• Fibroblasts 38%
• Carcinogens 37%
• Kidney 27%
• Chromosome Fragile Sites 23%
• DNA 21%
• INDEL Mutation 20%
• Alleles 19%
• 9,10-Dimethyl-1,2-benzanthracene 17%
• Point Mutation 12%
• Caspase 3 11%
• Genome 8%
• Cell Proliferation 8%
• Pressure 8%
• Apoptosis 7%
• Phenotype 7%
• Liver 6%
• In Vitro Techniques 5%
• Genes 5%

Chemical Compounds

• Mutation 76%
• Mutagenic Agent 73%
• Anthracene 44%
• Pressure 26%
• Environment 25%