Fetal ventricular diastolic filling characteristics in a primate model: The role of fetal heart rate and pulmonary vascular impedance

Jason N. Hashima, Antonio E. Frias, Leah Bernard, Eliot R. Spindel, Theodore R. Hobbs, Juha Rasanen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives: We hypothesized that fetal ventricular diastolic filling characteristics are related to fetal heart rate (FHR) and pulmonary vascular impedance. Methods: Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity waveforms were used to calculate maximum velocity (V-max) and velocity time integral (VTI) E/A ratios (early filling/ventricular filling during atrial contraction) at baseline and during maternal hyperoxygenation. Right pulmonary artery (RPA) pulsatility indices (PIs) and FHR were measured. Results: Hyperoxgenation significantly decreased FHR and RPA PI. The TV V-max and the MV VTI E/A ratios increased significantly and correlated with a decrease in FHR but not with a decrease in RPA PI. The TV and MV A-wave V-max decreased during hyperoxygenation and their decrease correlated significantly with a drop in FHR. Conclusions: Fetal ventricular diastolic filling characteristics are related to FHR but not to pulmonary vascular impedance.

Original languageEnglish (US)
Pages (from-to)760-766
Number of pages7
JournalReproductive Sciences
Volume17
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • Doppler
  • Echocardiography
  • fetal circulation
  • physiology
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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