Fetal schizencephaly

Pre- and postnatal imaging with a review of the clinical manifestations

Karen Oh, Anne M. Kennedy, Antonio Frias, Janice L B Byrne

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Schizencephaly is a rare malformation of the central nervous system. Prenatal ultrasound (US) allows diagnosis of schizencephaly, although prenatal magnetic resonance (MR) imaging is even more specific in detection of gray matter lining the defect, communication with the ventricle, and other associated structural abnormalities. Six cases of schizencephaly were evaluated at one institution; prenatal US was performed in all cases, and fetal MR imaging was performed in three cases. As with many malformations, more severe cases of schizencephaly often manifest in utero. All of the cases studied were of the open-lip variety; three cases were bilateral, and three were unilateral. The cleft was not appreciated at initial US in only one case, which consisted of a small unilateral defect, with the diagnosis made at subsequent MR imaging. A survey of the clinical literature on schizencephaly shows that the severity of the motor and mental impairments is directly related to the extent of the anatomic defect. The differential diagnosis for a cerebrospinal fluid-containing abnormality of the fetal brain includes both developmental and destructive lesions. Prenatal detection of schizencephaly can assist in management of the pregnancy.

Original languageEnglish (US)
Pages (from-to)647-657
Number of pages11
JournalRadiographics
Volume25
Issue number3
StatePublished - May 2005
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Lip
Cerebrospinal Fluid
Schizencephaly
Differential Diagnosis
Central Nervous System
Pregnancy
Brain
Surveys and Questionnaires
Gray Matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fetal schizencephaly : Pre- and postnatal imaging with a review of the clinical manifestations. / Oh, Karen; Kennedy, Anne M.; Frias, Antonio; Byrne, Janice L B.

In: Radiographics, Vol. 25, No. 3, 05.2005, p. 647-657.

Research output: Contribution to journalArticle

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