Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model

Amaryllis Maria Elpida Arraut, Antonio Frias, Theodore Hobbs, Cynthia (Cindy) McEvoy, Eliot Spindel, Juha Rasanen

Research output: Contribution to journalArticle

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Abstract

Objective: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. Study Design: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. Results: Fetal RPA PI values increased (P > .05) during maternal hypoxemia and decreased (P > .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P > .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. Conclusions: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalReproductive Sciences
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Keywords

  • Doppler echocardiography
  • fetal physiology
  • fetal pulmonary physiology
  • heart
  • hyperoxemia
  • hypoxemia
  • lung

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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