Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model

Amaryllis Maria Elpida Arraut, Antonio Frias, Theodore Hobbs, Cynthia (Cindy) McEvoy, Eliot Spindel, Juha Rasanen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. Study Design: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. Results: Fetal RPA PI values increased (P > .05) during maternal hypoxemia and decreased (P > .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P > .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. Conclusions: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalReproductive Sciences
Volume20
Issue number1
DOIs
StatePublished - Jan 2013

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Electric Impedance
Primates
Blood Vessels
Mothers
Ductus Arteriosus
Pregnancy
Lung
Umbilical Arteries
Pulmonary Circulation
Cardiac Output
Pulmonary Artery
Prenatal Ultrasonography
Doppler Ultrasonography
Macaca mulatta
Air
Hypoxia

Keywords

  • Doppler echocardiography
  • fetal physiology
  • fetal pulmonary physiology
  • heart
  • hyperoxemia
  • hypoxemia
  • lung

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model",
abstract = "Objective: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. Study Design: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. Results: Fetal RPA PI values increased (P > .05) during maternal hypoxemia and decreased (P > .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P > .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. Conclusions: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.",
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author = "Arraut, {Amaryllis Maria Elpida} and Antonio Frias and Theodore Hobbs and McEvoy, {Cynthia (Cindy)} and Eliot Spindel and Juha Rasanen",
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T1 - Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model

AU - Arraut, Amaryllis Maria Elpida

AU - Frias, Antonio

AU - Hobbs, Theodore

AU - McEvoy, Cynthia (Cindy)

AU - Spindel, Eliot

AU - Rasanen, Juha

PY - 2013/1

Y1 - 2013/1

N2 - Objective: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. Study Design: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. Results: Fetal RPA PI values increased (P > .05) during maternal hypoxemia and decreased (P > .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P > .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. Conclusions: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.

AB - Objective: We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation. Study Design: A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia. Results: Fetal RPA PI values increased (P > .05) during maternal hypoxemia and decreased (P > .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P > .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected. Conclusions: Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.

KW - Doppler echocardiography

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KW - fetal pulmonary physiology

KW - heart

KW - hyperoxemia

KW - hypoxemia

KW - lung

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