TY - JOUR
T1 - Fetal programming
T2 - Lung health and disease
AU - Yilmaz, Ozge
AU - Yuksel, Hasan
AU - Buist, A. Sonia
N1 - Publisher Copyright:
© 2021 by Turkish Thoracic Society-.
PY - 2021/9
Y1 - 2021/9
N2 - Fetal programming is a mechanism whereby stimuli acting on the developing fetus influence the development of the fetus in a way that may set the stage for adult health and disease. These stimuli may be environmental, such as maternal smoking; metabolic, such as the maternal diet and nutrition; or endocrine, such as diabetes or stress, and may extend over several generations. The endocrine system influences fetal programming with effects of insulin, thyroid hormones, and glucocorticoid hormones. Epigenetic information may be modified by DNA methylation, histone modifications, and micro RNAs due to environmental exposures. In this review, we describe the normal development of the lungs and the major factors that may influence lung growth and development with the potential for sequelae into adult life.
AB - Fetal programming is a mechanism whereby stimuli acting on the developing fetus influence the development of the fetus in a way that may set the stage for adult health and disease. These stimuli may be environmental, such as maternal smoking; metabolic, such as the maternal diet and nutrition; or endocrine, such as diabetes or stress, and may extend over several generations. The endocrine system influences fetal programming with effects of insulin, thyroid hormones, and glucocorticoid hormones. Epigenetic information may be modified by DNA methylation, histone modifications, and micro RNAs due to environmental exposures. In this review, we describe the normal development of the lungs and the major factors that may influence lung growth and development with the potential for sequelae into adult life.
KW - Environment
KW - Epigenetics
KW - Exposure
KW - Fetal programming
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U2 - 10.5152/TurkThoracJ.2021.0196
DO - 10.5152/TurkThoracJ.2021.0196
M3 - Review article
AN - SCOPUS:85116060190
SN - 2149-2530
VL - 22
SP - 413
EP - 417
JO - Turkish Thoracic Journal
JF - Turkish Thoracic Journal
IS - 5
ER -