Fetal lamb ventricles respond differently to filling and arterial pressures and to in utero ventilation

Mark Reller, M. J. Morton, D. L. Reid, Kent Thornburg

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Right and left ventricular function were investigated in 12 fetal lambs (127-140 days gestation) instrumented with electromagnetic flow sensors on the ascending aorta and the main pulmonary artery, and with vascular catheters. Nine fetuses were equippped with a postductal aortic occluder and the trachea was cannulated in eight. Control arterial blood values were pH 7.36 ± 0.02 (SD), PCO2 49.3 ± 2.3 torr, PO2 18.4 ± 1.7 torr, and hematocrit 37.3 ± 4.4%. Biventricular function curves relating stroke volume to mean right and left artrial pressure were generated by rapid withdrawal and reinfusion of fetal blood. Both function curves were composed of steep ascending and plateau limbs that intersected at a breakpoint. Stroke volumes at the breakpoints were 0.94 ± 0.19 ml·kg-1 and 0.63 ± 0.15 ml·kg-1 for right and left ventricle, respectively (p <0.001). During postductal aortic occlusion, arterial pressure increased by 19.3 ± 7.9 torr while right ventricular stroke volume decreased by Υ48% and left ventricular stroke volume decreased by Υ9%. In utero ventilation increased arterial pressure, heart rate, PO2, and oxygen content. Right atrial pressure increased from 3.9 ± 1.3 to 5.8 ± 2.9 torr (p <0.05); left atrial pressure from 3.5 ± 1.5 to 10.0 ± 4.4 torr (p <0.05). Aortic flow nearly doubled (112 ± 29 to 211 ± 35 ml·min-1·kg-1)(p , 0.05), and the left ventricular function curve shifted upward. The right ventricular function curve was shifted downward during ventilation. We conclude that the fetal ventricles differ significantly in their outputs, response to changes in arterial pressure, and to the onset of inutero ventilation.

Original languageEnglish (US)
Pages (from-to)621-626
Number of pages6
JournalPediatric Research
Volume22
Issue number6
StatePublished - 1987

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Stroke Volume
Ventilation
Arterial Pressure
Right Ventricular Function
Atrial Pressure
Left Ventricular Function
Heart Ventricles
Vascular Access Devices
Electromagnetic Phenomena
Trachea
Fetal Blood
Hematocrit
Pulmonary Artery
Aorta
Fetus
Extremities
Heart Rate
Oxygen
Pressure
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Fetal lamb ventricles respond differently to filling and arterial pressures and to in utero ventilation. / Reller, Mark; Morton, M. J.; Reid, D. L.; Thornburg, Kent.

In: Pediatric Research, Vol. 22, No. 6, 1987, p. 621-626.

Research output: Contribution to journalArticle

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abstract = "Right and left ventricular function were investigated in 12 fetal lambs (127-140 days gestation) instrumented with electromagnetic flow sensors on the ascending aorta and the main pulmonary artery, and with vascular catheters. Nine fetuses were equippped with a postductal aortic occluder and the trachea was cannulated in eight. Control arterial blood values were pH 7.36 ± 0.02 (SD), PCO2 49.3 ± 2.3 torr, PO2 18.4 ± 1.7 torr, and hematocrit 37.3 ± 4.4{\%}. Biventricular function curves relating stroke volume to mean right and left artrial pressure were generated by rapid withdrawal and reinfusion of fetal blood. Both function curves were composed of steep ascending and plateau limbs that intersected at a breakpoint. Stroke volumes at the breakpoints were 0.94 ± 0.19 ml·kg-1 and 0.63 ± 0.15 ml·kg-1 for right and left ventricle, respectively (p <0.001). During postductal aortic occlusion, arterial pressure increased by 19.3 ± 7.9 torr while right ventricular stroke volume decreased by Υ48{\%} and left ventricular stroke volume decreased by Υ9{\%}. In utero ventilation increased arterial pressure, heart rate, PO2, and oxygen content. Right atrial pressure increased from 3.9 ± 1.3 to 5.8 ± 2.9 torr (p <0.05); left atrial pressure from 3.5 ± 1.5 to 10.0 ± 4.4 torr (p <0.05). Aortic flow nearly doubled (112 ± 29 to 211 ± 35 ml·min-1·kg-1)(p , 0.05), and the left ventricular function curve shifted upward. The right ventricular function curve was shifted downward during ventilation. We conclude that the fetal ventricles differ significantly in their outputs, response to changes in arterial pressure, and to the onset of inutero ventilation.",
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