Fetal heart rate and umbilical blood flow

J. H G Rankin, M. K. Stock, Debra Anderson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It has been suggested previously that norepinephrine does not change fetal placental vascular resistance but does change placental blood flow by changing fetal heart rate. We have tested the hypthesis that fetal heart rate is a determinant of fetal placental blood flow by observing changes in placental vascular resistance in 10 chronically catheterized near-term sheep fetuses. Pressures and flow were observed in the control condition and 150 s after the initiation of infusion of norepinephrine at 50 μg/min. The fetuses were then given 1.5 mg of atropine and control observations were again made. The norepinephrine infusion was repeated and pressure and blood flows were measured after 150' s. Atropine increased the fetal heart rate from 168 ± 6 to 205 ± 12 beats/min. Placental vascular resistance did not change. Norepinephrine resulted in bradycardia, hypertension and an increased placental vascular resistance. After pretreatment with atropine, norepinephrine resulted in tachycardia, hypertension and an increased placental vascular resistance. We conclude that fetal heart rate is not a major determinant of blood flow and that high doses of norepinephrine cause vasoconstriction of the placental vascular bed of the near-term sheep fetus.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalJournal of Developmental Physiology
Volume2
Issue number1-2
StatePublished - 1980
Externally publishedYes

Fingerprint

Umbilicus
Fetal Heart Rate
Norepinephrine
Vascular Resistance
Atropine
Fetus
Sheep
Hypertension
Bradycardia
Vasoconstriction
Fetal Blood
Tachycardia
Blood Vessels
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Rankin, J. H. G., Stock, M. K., & Anderson, D. (1980). Fetal heart rate and umbilical blood flow. Journal of Developmental Physiology, 2(1-2), 11-16.

Fetal heart rate and umbilical blood flow. / Rankin, J. H G; Stock, M. K.; Anderson, Debra.

In: Journal of Developmental Physiology, Vol. 2, No. 1-2, 1980, p. 11-16.

Research output: Contribution to journalArticle

Rankin, JHG, Stock, MK & Anderson, D 1980, 'Fetal heart rate and umbilical blood flow', Journal of Developmental Physiology, vol. 2, no. 1-2, pp. 11-16.
Rankin JHG, Stock MK, Anderson D. Fetal heart rate and umbilical blood flow. Journal of Developmental Physiology. 1980;2(1-2):11-16.
Rankin, J. H G ; Stock, M. K. ; Anderson, Debra. / Fetal heart rate and umbilical blood flow. In: Journal of Developmental Physiology. 1980 ; Vol. 2, No. 1-2. pp. 11-16.
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