Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep

Gert S. Maritz, Megan L. Cock, Samantha Louey, Keiji Suzuki, Richard Harding

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41% lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28% fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10% reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82% increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalPediatric Research
Volume55
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Fetal Development
Sheep
Lung
Parturition
Blood-Air Barrier
Basement Membrane
Birth Weight
Extracellular Matrix
Fetus
Body Weight
Pregnancy
Health

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep. / Maritz, Gert S.; Cock, Megan L.; Louey, Samantha; Suzuki, Keiji; Harding, Richard.

In: Pediatric Research, Vol. 55, No. 2, 02.2004, p. 287-295.

Research output: Contribution to journalArticle

Maritz, Gert S. ; Cock, Megan L. ; Louey, Samantha ; Suzuki, Keiji ; Harding, Richard. / Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep. In: Pediatric Research. 2004 ; Vol. 55, No. 2. pp. 287-295.
@article{01174433c8e34ac282d06f0c142d63e3,
title = "Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep",
abstract = "We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41{\%} lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28{\%} fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10{\%} reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82{\%} increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life.",
author = "Maritz, {Gert S.} and Cock, {Megan L.} and Samantha Louey and Keiji Suzuki and Richard Harding",
year = "2004",
month = "2",
doi = "10.1203/01.PDR.0000106314.99930.65",
language = "English (US)",
volume = "55",
pages = "287--295",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep

AU - Maritz, Gert S.

AU - Cock, Megan L.

AU - Louey, Samantha

AU - Suzuki, Keiji

AU - Harding, Richard

PY - 2004/2

Y1 - 2004/2

N2 - We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41% lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28% fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10% reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82% increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life.

AB - We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41% lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28% fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10% reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82% increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life.

UR - http://www.scopus.com/inward/record.url?scp=1642433279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642433279&partnerID=8YFLogxK

U2 - 10.1203/01.PDR.0000106314.99930.65

DO - 10.1203/01.PDR.0000106314.99930.65

M3 - Article

VL - 55

SP - 287

EP - 295

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 2

ER -