Fetal cerebral blood flow and metabolism during oligemia and early postoligemic reperfusion

Conrad R. Chao, Alan (Roger) Hohimer, John M. Bissonnette

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The early time period following ischemia may he of pathogenetic importance in hypoxic-ischemia brain injury. Global cerebral oligemia was induced in ten late gestation fetal sheep by inflation of a balloon occluder around the brachiocephalic artery. Cerebral blood flow, oxygen, glucose, and lactate net flux, and oxygen delivery were measured by the Fick principle following 1 h of oligemia and at 5, 30, and 60 min of postoligemic reperfusion. During oligemia, cerebral blood flow decreased by 74 ± 10% (mean ± SD) and oxygen consumption decreased by 34 ± 24%. The glucose:oxygen quotient was elevated throughout the oligemic period. In the early (5 min) reperfusion period, blood flow and oxygen delivery were not different from control but oxygen consumption was persistently depressed by 27 ± 32%; fractional extraction of oxygen was 0.38 ± 0.10 during control and 0.24 ± 0.09 during early reperfusion. The venous oxygen tension increased modestly from 15.2 ± 2.4 to 18.0 ± 1.7 mm Hg; the postoligemic venous pO2 was limited by the lack of reactive hyperemia combined with the low arterial pO2 of the intrauterine environment. Postoligemic carbohydrate fluxes could not be differentiated from control, possibly due to blood-brain barrier limitations. These factors may be related to the relative resistance of the fetal brain to hypoxic-ischemic injury.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume11
Issue number3
StatePublished - 1991

Fingerprint

Cerebrovascular Circulation
Fetal Blood
Reperfusion
Oxygen
Oxygen Consumption
Ischemia
Glucose
Hyperemia
Economic Inflation
Blood-Brain Barrier
Brain Injuries
Lactic Acid
Sheep
Arteries
Carbohydrates
Pregnancy
Wounds and Injuries
Brain

Keywords

  • Cerebral metabolism
  • Fetal brain
  • Glucose
  • Hypoxia
  • Ischemia
  • Reperfusion

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

Fetal cerebral blood flow and metabolism during oligemia and early postoligemic reperfusion. / Chao, Conrad R.; Hohimer, Alan (Roger); Bissonnette, John M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 11, No. 3, 1991, p. 416-423.

Research output: Contribution to journalArticle

Chao, Conrad R. ; Hohimer, Alan (Roger) ; Bissonnette, John M. / Fetal cerebral blood flow and metabolism during oligemia and early postoligemic reperfusion. In: Journal of Cerebral Blood Flow and Metabolism. 1991 ; Vol. 11, No. 3. pp. 416-423.
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