Fetal cardiac development and hemodynamics in the first trimester

M. C. Leiva, Jorge Tolosa, C. N. Binotto, S. Weiner, L. Huppert, A. L. Denis, J. C. Huhta

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective. To describe fetal cardiac and hemodynamic development in the first trimester of pregnancy. Subjects and methods. Forty-eight pregnancies were prospectively studied with transvaginal ultrasound and color Doppler. Fetal heart rate and size were documented together with the presence of inflow and outflow wave-forms and valve signals. Results. Heart rate and size showed a positive correlation with gestational age. At 6 weeks of gestation, 20% of the cardiac cycle was occupied by the isovolumic contraction time (ICT); the isovolumic relaxation time (IRT) occupied 16% and remained unchanged, while the ICT progressively shortened and was not measurable after 12 weeks. The peak inflow velocities had changed from monophasic to biphasic by 10 weeks of gestation. At 7 weeks of gestation, semilunar valves were detected in 3%. The detection rate for both valves at 12 weeks was ≥ 90%. In pregnancies that miscarried, the detection rate for both was <25%. Conclusion. The Doppler signals that characterize the heart during the first trimester suggest effective heart compliance by 12 weeks. Normal valve development can be inferred from non-invasive Doppler recordings.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Volume14
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

hemodynamics
First Pregnancy Trimester
Fetal Development
pregnancy
Hemodynamics
Pregnancy
heart rate
contraction
Doppler Ultrasonography
Fetal Heart Rate
relaxation time
recording
Gestational Age
Compliance
color
Color
cycles
Heart Rate

Keywords

  • Cardiac
  • Fetus
  • First trimester
  • Heart
  • Hemodynamics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

Leiva, M. C., Tolosa, J., Binotto, C. N., Weiner, S., Huppert, L., Denis, A. L., & Huhta, J. C. (1999). Fetal cardiac development and hemodynamics in the first trimester. Ultrasound in Obstetrics and Gynecology, 14(3), 169-174. https://doi.org/10.1046/j.1469-0705.1999.14030169.x

Fetal cardiac development and hemodynamics in the first trimester. / Leiva, M. C.; Tolosa, Jorge; Binotto, C. N.; Weiner, S.; Huppert, L.; Denis, A. L.; Huhta, J. C.

In: Ultrasound in Obstetrics and Gynecology, Vol. 14, No. 3, 1999, p. 169-174.

Research output: Contribution to journalArticle

Leiva, M. C. ; Tolosa, Jorge ; Binotto, C. N. ; Weiner, S. ; Huppert, L. ; Denis, A. L. ; Huhta, J. C. / Fetal cardiac development and hemodynamics in the first trimester. In: Ultrasound in Obstetrics and Gynecology. 1999 ; Vol. 14, No. 3. pp. 169-174.
@article{55e16f71829e42c89adaa1e5c0f89765,
title = "Fetal cardiac development and hemodynamics in the first trimester",
abstract = "Objective. To describe fetal cardiac and hemodynamic development in the first trimester of pregnancy. Subjects and methods. Forty-eight pregnancies were prospectively studied with transvaginal ultrasound and color Doppler. Fetal heart rate and size were documented together with the presence of inflow and outflow wave-forms and valve signals. Results. Heart rate and size showed a positive correlation with gestational age. At 6 weeks of gestation, 20{\%} of the cardiac cycle was occupied by the isovolumic contraction time (ICT); the isovolumic relaxation time (IRT) occupied 16{\%} and remained unchanged, while the ICT progressively shortened and was not measurable after 12 weeks. The peak inflow velocities had changed from monophasic to biphasic by 10 weeks of gestation. At 7 weeks of gestation, semilunar valves were detected in 3{\%}. The detection rate for both valves at 12 weeks was ≥ 90{\%}. In pregnancies that miscarried, the detection rate for both was <25{\%}. Conclusion. The Doppler signals that characterize the heart during the first trimester suggest effective heart compliance by 12 weeks. Normal valve development can be inferred from non-invasive Doppler recordings.",
keywords = "Cardiac, Fetus, First trimester, Heart, Hemodynamics",
author = "Leiva, {M. C.} and Jorge Tolosa and Binotto, {C. N.} and S. Weiner and L. Huppert and Denis, {A. L.} and Huhta, {J. C.}",
year = "1999",
doi = "10.1046/j.1469-0705.1999.14030169.x",
language = "English (US)",
volume = "14",
pages = "169--174",
journal = "Ultrasound in Obstetrics and Gynecology",
issn = "0960-7692",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Fetal cardiac development and hemodynamics in the first trimester

AU - Leiva, M. C.

AU - Tolosa, Jorge

AU - Binotto, C. N.

AU - Weiner, S.

AU - Huppert, L.

AU - Denis, A. L.

AU - Huhta, J. C.

PY - 1999

Y1 - 1999

N2 - Objective. To describe fetal cardiac and hemodynamic development in the first trimester of pregnancy. Subjects and methods. Forty-eight pregnancies were prospectively studied with transvaginal ultrasound and color Doppler. Fetal heart rate and size were documented together with the presence of inflow and outflow wave-forms and valve signals. Results. Heart rate and size showed a positive correlation with gestational age. At 6 weeks of gestation, 20% of the cardiac cycle was occupied by the isovolumic contraction time (ICT); the isovolumic relaxation time (IRT) occupied 16% and remained unchanged, while the ICT progressively shortened and was not measurable after 12 weeks. The peak inflow velocities had changed from monophasic to biphasic by 10 weeks of gestation. At 7 weeks of gestation, semilunar valves were detected in 3%. The detection rate for both valves at 12 weeks was ≥ 90%. In pregnancies that miscarried, the detection rate for both was <25%. Conclusion. The Doppler signals that characterize the heart during the first trimester suggest effective heart compliance by 12 weeks. Normal valve development can be inferred from non-invasive Doppler recordings.

AB - Objective. To describe fetal cardiac and hemodynamic development in the first trimester of pregnancy. Subjects and methods. Forty-eight pregnancies were prospectively studied with transvaginal ultrasound and color Doppler. Fetal heart rate and size were documented together with the presence of inflow and outflow wave-forms and valve signals. Results. Heart rate and size showed a positive correlation with gestational age. At 6 weeks of gestation, 20% of the cardiac cycle was occupied by the isovolumic contraction time (ICT); the isovolumic relaxation time (IRT) occupied 16% and remained unchanged, while the ICT progressively shortened and was not measurable after 12 weeks. The peak inflow velocities had changed from monophasic to biphasic by 10 weeks of gestation. At 7 weeks of gestation, semilunar valves were detected in 3%. The detection rate for both valves at 12 weeks was ≥ 90%. In pregnancies that miscarried, the detection rate for both was <25%. Conclusion. The Doppler signals that characterize the heart during the first trimester suggest effective heart compliance by 12 weeks. Normal valve development can be inferred from non-invasive Doppler recordings.

KW - Cardiac

KW - Fetus

KW - First trimester

KW - Heart

KW - Hemodynamics

UR - http://www.scopus.com/inward/record.url?scp=0032710377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032710377&partnerID=8YFLogxK

U2 - 10.1046/j.1469-0705.1999.14030169.x

DO - 10.1046/j.1469-0705.1999.14030169.x

M3 - Article

VL - 14

SP - 169

EP - 174

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 3

ER -