Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations

COMMITTEE ON BIOETHICS; Section on Hematology/Oncology; Section on Surgery

doi:10.1542/peds.2019-3994

Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations

COMMITTEE ON BIOETHICS, Section on Hematology/Oncology, Section on Surgery

Pediatrics

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.

Original language	English (US)
Article number	e20193994
Journal	Pediatrics
Volume	145
Issue number	3
DOIs	https://doi.org/10.1542/peds.2019-3994
State	Published - Mar 1 2020

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1542/peds.2019-3994

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title = "Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations",

abstract = "Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.",

author = "{COMMITTEE ON BIOETHICS} and {Section on Hematology/Oncology} and {Section on Surgery} and Sigal Klipstein and Fallat, {Mary E.} and Stephanie Savelli and Katz, {Aviva L.} and MacAuley, {Robert C.} and Mercurio, {Mark R.} and Moon, {Margaret R.} and Okun, {Alexander L.} and Weise, {Kathryn L.} and Rogers, {Zora R.} and Carl Allen and James Harper and Jeffrey Lipton and Cynthia Wetmore and Hope Wilson and Amber Yates and Rescorla, {Frederick J.} and Brandt, {Mary L.} and Michael Caty and Kurt Heiss and Holcomb, {George W.} and Meyers, {Rebecca L.} and Moss, {R. Lawrence}",

year = "2020",

month = mar,

day = "1",

doi = "10.1542/peds.2019-3994",

language = "English (US)",

volume = "145",

journal = "Pediatrics",

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publisher = "American Academy of Pediatrics",

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TY - JOUR

T1 - Fertility preservation for pediatric and adolescent patients with cancer

T2 - Medical and ethical considerations

AU - COMMITTEE ON BIOETHICS

AU - Section on Hematology/Oncology

AU - Section on Surgery

AU - Klipstein, Sigal

AU - Fallat, Mary E.

AU - Savelli, Stephanie

AU - Katz, Aviva L.

AU - MacAuley, Robert C.

AU - Mercurio, Mark R.

AU - Moon, Margaret R.

AU - Okun, Alexander L.

AU - Weise, Kathryn L.

AU - Rogers, Zora R.

AU - Allen, Carl

AU - Harper, James

AU - Lipton, Jeffrey

AU - Wetmore, Cynthia

AU - Wilson, Hope

AU - Yates, Amber

AU - Rescorla, Frederick J.

AU - Brandt, Mary L.

AU - Caty, Michael

AU - Heiss, Kurt

AU - Holcomb, George W.

AU - Meyers, Rebecca L.

AU - Moss, R. Lawrence

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.

AB - Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.

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M3 - Review article

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AN - SCOPUS:85081131126

SN - 0031-4005

VL - 145

JO - Pediatrics

JF - Pediatrics

IS - 3

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ER -

Fertility preservation for pediatric and adolescent patients with cancer: Medical and ethical considerations

Abstract

ASJC Scopus subject areas

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