Femoral volumetric bone density, geometry, and strength in relation to 25-hydroxy vitamin D in older men

Elizabeth N. Martin, Elizabeth Haney, Jackilen (Jackie) Shannon, Jane A. Cauley, Kristine E. Ensrud, Tony M. Keaveny, Joseph M. Zmuda, Eric Orwoll, Stephanie Litwack Harrison, Lynn Marshall

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Low serum 25-hydroxy vitamin D (25(OH)D) concentrations are associated with increased hip fracture risk and decreased femoral areal bone mineral density (BMD) among elderly men. Structural dimensions of the proximal femur and volumetric BMD in cortical and trabecular compartments are also associated with hip fracture risk. However, associations of volumetric BMD or structural dimensions with serum 25(OH)D concentrations among older men remain unclear. In a random sample of 1608 men aged -65 years from the Osteoporotic Fractures in Men Study (MrOS), baseline serum 25(OH)D concentrations were measured by liquid chromatography/mass spectrometry assays. Femoral neck geometry and volumetric BMD derived from quantitative computed tomography included integral, cortical, and trabecular volumetric BMD; cross-sectional area; integral and cortical volume; and cortical volume as a percent of integral volume. We studied 888 men with vitamin D, parathyroid hormone (PTH), femoral neck geometry, and BMD measures. Whole-bone femoral strength and load-strength ratio from finite element (FE) analysis were also available for 356 men from this sample. Multivariable linear regression was used to estimate least square means of each femoral measure within quartiles of 25(OH)D adjusted for age, race, body mass index, height, latitude, and season of blood draw. Tests of linear trend in the means were performed across increasing quartile of serum 25(OH)D levels. Mean cortical volume (p trend=0.006) and cortical volume as a percent of integral volume (p trend

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalJournal of Bone and Mineral Research
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Thigh
Vitamin D
Bone Density
Femur Neck
Hip Fractures
Serum
Finite Element Analysis
Osteoporotic Fractures
Least-Squares Analysis
Parathyroid Hormone
Liquid Chromatography
Femur
Linear Models
Mass Spectrometry
Body Mass Index
Tomography
Bone and Bones

Keywords

  • 25(OH)D
  • Femoral strength
  • Femoral volumetric BMD
  • Finite element analysis
  • Men
  • Parathyroid hormone QCT

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Femoral volumetric bone density, geometry, and strength in relation to 25-hydroxy vitamin D in older men. / Martin, Elizabeth N.; Haney, Elizabeth; Shannon, Jackilen (Jackie); Cauley, Jane A.; Ensrud, Kristine E.; Keaveny, Tony M.; Zmuda, Joseph M.; Orwoll, Eric; Harrison, Stephanie Litwack; Marshall, Lynn.

In: Journal of Bone and Mineral Research, Vol. 30, No. 3, 01.03.2015, p. 475-482.

Research output: Contribution to journalArticle

Martin, Elizabeth N. ; Haney, Elizabeth ; Shannon, Jackilen (Jackie) ; Cauley, Jane A. ; Ensrud, Kristine E. ; Keaveny, Tony M. ; Zmuda, Joseph M. ; Orwoll, Eric ; Harrison, Stephanie Litwack ; Marshall, Lynn. / Femoral volumetric bone density, geometry, and strength in relation to 25-hydroxy vitamin D in older men. In: Journal of Bone and Mineral Research. 2015 ; Vol. 30, No. 3. pp. 475-482.
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