Feeding impairments associated with plasma sterols in smith-lemli-opitz syndrome

Mark Merkens, Nancy L. Sinden, Christine D. Brown, Louise S. Merkens, Jean-Baptiste Roullet, Thuan Nguyen, Robert D. Steiner

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective To quantitatively evaluate feeding impairment in children with Smith-Lemli-Opitz syndrome (SLOS) and to correlate feeding impairment with clinical and biochemical indices of disease severity.

Study design The study subjects were 26 children with SLOS ranging in age from 0.4 to 19 years. Clinical severity was measured using an existing scoring system. We created a tool to quantitatively evaluate feeding. Plasma sterol concentrations were measured, and statistical associations (correlations) with feeding scores were calculated.

Results Oral hyposensitivity or hypersensitivity, adverse behaviors, and risk for dysphagia were seen in ∼65% of the children with SLOS. Thirteen of the 26 children experienced failure to thrive, and 10 children required gastrostomy. Plasma concentration of 7-dehydrocholesterol, as a measure of severity, was correlated with total feeding score and oral function subcategory score (P 0.24 mmol/L or cholesterol concentration

Conclusion Feeding impairment is common and complex in patients with SLOS. Our findings confirm that oral sensitivities, adverse feeding behaviors, and risk of oral phase dysphagia are amenable to quantitative evaluation and analysis. Feeding difficulties in children with SLOS are correlated with plasma sterol concentrations, suggesting a link between the biochemical severity of SLOS and feeding function. These findings expand the behavioral phenotype of SLOS and begin to provide insight into the biological causes of feeding difficulties.

Original languageEnglish (US)
Pages (from-to)836-841.e1
JournalJournal of Pediatrics
Volume165
Issue number4
DOIs
Publication statusPublished - Oct 1 2014

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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