Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease

David L. Suskind, Mitchell J. Brittnacher, Ghassan Wahbeh, Michele L. Shaffer, Hillary S. Hayden, Xuan Qin, Namita Singh, Christopher J. Damman, Kyle R. Hager, Heather Nielson, Samuel I. Miller

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Background: Crohn's disease (CD) is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Fecal microbial transplant (FMT) is a potential therapeutic option for individuals with CD based on the hypothesis that changing the fecal dysbiosis could promote less intestinal inflammation. Methods: Nine patients, aged 12 to 19 years, with mild-to-moderate symptoms defined by Pediatric Crohn's Disease Activity Index (PCDAI of 10-29) were enrolled into a prospective open-label study of FMT in CD (FDA IND 14942). Patients received FMT by nasogastric tube with follow-up evaluations at 2, 6, and 12 weeks. PCDAI, C-reactive protein, and fecal calprotectin were evaluated at each study visit. Results: All reported adverse events were graded as mild except for 1 individual who reported moderate abdominal pain after FMT. All adverse events were self-limiting. Metagenomic evaluation of stool microbiome indicated evidence of FMT engraftment in 7 of 9 patients. The mean PCDAI score improved with patients having a baseline of 19.7 ± 7.2, with improvement at 2 weeks to 6.4 ± 6.6 and at 6 weeks to 8.6 ± 4.9. Based on PCDAI, 7 of 9 patients were in remission at 2 weeks and 5 of 9 patients who did not receive additional medical therapy were in remission at 6 and 12 weeks. No or modest improvement was seen in patients who did not engraft or whose microbiome was most similar to their donor. Conclusions: This is the first study to demonstrate that FMT for CD may be a possible therapeutic option for CD. Further prospective studies are required to fully assess the safety and efficacy of the FMT in patients with CD.

Original languageEnglish (US)
Pages (from-to)556-563
Number of pages8
JournalInflammatory Bowel Diseases
Volume21
Issue number3
DOIs
StatePublished - Jan 9 2015
Externally publishedYes

Keywords

  • Crohn's disease
  • FMT
  • fecal microbial transplant
  • fecal microbiome
  • inflammatory bowel disease
  • pediatrics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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