February 2000

Dementia with motor dysfunction in a patient with liver disease

David Spencer, Lysis S. Forno

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Acquired (non-Wilsonian) hepatocerebral degeneration (AHCD) is an irreversible neurological condition characterized by dementia, dysarthria, and motor disturbances. It has been described in patients with severe liver disease of many causes, and notably in patients with surgically or spontaneously created porto-systemic shunts. We report a case of AHCD in a patient with end-stage liver disease due to alcohol abuse and hepatitis C. In addition, this patient showed pathologic evidence of the less commonly reported 'shunt myelopathy' in the absence of a surgically created porto- systemic shunt. The myelopathy was associated with a dramatic vacuolation involving especially the deep motor cortex. Electron microscopy suggested that the vacuolation was due mainly to disruption of abnormal astrocytes.

Original languageEnglish (US)
Pages (from-to)315-316+319
JournalBrain Pathology
Volume10
Issue number2
StatePublished - Apr 2000
Externally publishedYes

Fingerprint

Dementia
Liver Diseases
Hepatolenticular Degeneration
Spinal Cord Diseases
Dysarthria
End Stage Liver Disease
Motor Cortex
Hepatitis C
Astrocytes
Alcoholism
Electron Microscopy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

February 2000 : Dementia with motor dysfunction in a patient with liver disease. / Spencer, David; Forno, Lysis S.

In: Brain Pathology, Vol. 10, No. 2, 04.2000, p. 315-316+319.

Research output: Contribution to journalArticle

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