Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity

Matthew S. Clifton, Bonnie N. Joe, Andrew S. Zektzer, John Kurhanewicz, Daniel B. Vigneron, Fergus Coakley, Kerilyn K. Nobuhara, Mark G. Swanson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background/Purpose: Amniocentesis is an invasive procedure with inherent risks. Magnetic resonance (MR) spectroscopy is a safe noninvasive way of measuring levels of choline-containing compounds (including surfactant) and other metabolites. The purpose of this study was to test the feasibility of assessing fetal lung maturity in vivo and ex vivo using MR spectroscopy to determine differences in amniotic fluid choline concentrations between the second and third trimesters. Methods: Magnetic resonance spectroscopy was performed on ex vivo samples of amniotic fluid from second- and third-trimester fetuses. In vivo MR spectroscopy was performed on amniotic fluid and fetal lungs in third-trimester fetuses. Spectral acquisition and analysis were performed by an attending radiologist in conjunction with an MR spectroscopist. Results: Choline-containing compounds were observed from 3.20 to 3.25 ppm. Comparison of spectra from second- and third-trimester amniocentesis revealed a trend toward increased choline at later gestational ages. Spectra from amniotic fluid and lungs of a third-trimester fetus showed that choline can be detected in the in vivo setting. Conclusions: Magnetic resonance spectroscopy is a safe noninvasive procedure that enables measurement of choline-containing compounds in fetal lung and amniotic fluid. Magnetic resonance spectroscopy shows a trend toward an increased quantity of choline in third- vs second-trimester amniocentesis.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalJournal of Pediatric Surgery
Volume41
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Choline
Magnetic Resonance Spectroscopy
Third Pregnancy Trimester
Amniotic Fluid
Lung
Second Pregnancy Trimester
Amniocentesis
Fetus
Surface-Active Agents
Gestational Age

Keywords

  • Amniocentesis
  • Choline
  • Fetal lung maturity
  • MR spectroscopy

ASJC Scopus subject areas

  • Surgery

Cite this

Clifton, M. S., Joe, B. N., Zektzer, A. S., Kurhanewicz, J., Vigneron, D. B., Coakley, F., ... Swanson, M. G. (2006). Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity. Journal of Pediatric Surgery, 41(4), 768-773. https://doi.org/10.1016/j.jpedsurg.2006.02.020

Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity. / Clifton, Matthew S.; Joe, Bonnie N.; Zektzer, Andrew S.; Kurhanewicz, John; Vigneron, Daniel B.; Coakley, Fergus; Nobuhara, Kerilyn K.; Swanson, Mark G.

In: Journal of Pediatric Surgery, Vol. 41, No. 4, 04.2006, p. 768-773.

Research output: Contribution to journalArticle

Clifton, MS, Joe, BN, Zektzer, AS, Kurhanewicz, J, Vigneron, DB, Coakley, F, Nobuhara, KK & Swanson, MG 2006, 'Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity', Journal of Pediatric Surgery, vol. 41, no. 4, pp. 768-773. https://doi.org/10.1016/j.jpedsurg.2006.02.020
Clifton, Matthew S. ; Joe, Bonnie N. ; Zektzer, Andrew S. ; Kurhanewicz, John ; Vigneron, Daniel B. ; Coakley, Fergus ; Nobuhara, Kerilyn K. ; Swanson, Mark G. / Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 4. pp. 768-773.
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