@article{08a6347f53c14363838fc36ea03a0430,
title = "FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis",
abstract = "Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we report that B cells and humoral immunity foster cancer development by activating Fcγ receptors (FcγRs) on resident and recruited myeloid cells. Stromal accumulation of autoantibodies in premalignant skin, through their interaction with activating FcγRs, regulate recruitment, composition, and bioeffector functions of leukocytes in neoplastic tissue, which in turn promote neoplastic progression and subsequent carcinoma development. These findings support a model in which B cells, humoral immunity, and activating FcγRs are required for establishing chronic inflammatory programs that promote de novo carcinogenesis.",
keywords = "CELLCYCLE, CELLIMMUNO, MOLIMMUNO",
author = "Pauline Andreu and Magnus Johansson and Affara, {Nesrine I.} and Ferdinando Pucci and Tingting Tan and Simon Junankar and Lidiya Korets and Julia Lam and David Tawfik and DeNardo, {David G.} and Luigi Naldini and {de Visser}, {Karin E.} and {De Palma}, Michele and Coussens, {Lisa M.}",
note = "Funding Information: The authors thank the University of California San Francisco Helen Diller Family Comprehensive Cancer Center Laboratory for Cell Analysis and Mouse Pathology shared resource core facilities and members of the Coussens laboratory for critical discussion. The authors acknowledge support from the Cancer Research Institute (P.A.), the Swedish Research Council (M.J.), the American Association for Cancer Research (N.I.A.), the American Cancer Society and National Cancer Institute postdoctoral training grants (T32-CA09043 and T32-CA108462; D.D.), the National Institutes of Health/National Cancer Institute grants (R01CA130980, R01CA13256, R01CA098075, and P01CA72006), and the Department of Defense Breast Cancer Research Program Era of Hope Scholar Award (W81XWH-06-1-0416; L.M.C.). L.N. and M.D.P. were supported by the Associazione Italiana per la Ricerca sul Cancro, the European Union (FP6 Tumor-Host Genomics), and the Italian Ministry of Health (Challenge in Oncology). ",
year = "2010",
month = feb,
day = "17",
doi = "10.1016/j.ccr.2009.12.019",
language = "English (US)",
volume = "17",
pages = "121--134",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}