Fc-dependent inhibition of mouse B cell activation by whole anti-μ antibodies

N. E. Phillips, D. C. Parker

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

We have been using whole rabbit anti-mouse μ antibodies to study Fc-dependent inhibition of mouse B cell activation by F(ab')2 anti-μ antibodies and antigen-nonspecific helper factors (SN). We show here that this inhibition does not appear to require adherent cells, appears to occur independently of cellular interactions, is reversible, and is not maintained solely by suppressive factors. In addition, occupancy of Fc receptors by rabbit antibody-antigen complexes is not sufficient to inhibit activation by F(ab')2 anti-μ and SN. These observations, in conjunction with the observation that blocking the Fc receptor-binding capacity of rabbit anti-μ antibodies by protein A prevents inhibition, suggest that cross-linking mIg and Fcγ receptors on B cells prevents activation. However, the F(ab')2 anti-μ and SN-activated B cells become refractory to this inhibition by 48 hr in culture.

Original languageEnglish (US)
Pages (from-to)602-606
Number of pages5
JournalJournal of Immunology
Volume130
Issue number2
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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