Fcγ receptor effects on induction of c-myc mRNA expression in mouse B lymphocytes by anti-immunoglobulin

Nancy E. Phillips, David Parker

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Levels of c-myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab'2 anti-Ig or IgG anti-Ig. Fab'2 anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab'2 fragment and the IgG anti-Ig induce an increase in c-myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab'2 anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab'2 anti-Ig remained elevated.

Original languageEnglish (US)
Pages (from-to)1199-1205
Number of pages7
JournalMolecular Immunology
Volume24
Issue number11
DOIs
Publication statusPublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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