Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

Melissa D. Murphy, Mary O'Hearn, Sunwen Chou

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

We describe a 49-year-old man with human immunodeficiency virus infection and stable chronic renal insufficiency who developed acute oliguric renal failure and severe lactic acidosis and who died several weeks after tenofovir was added to an antiretroviral regimen that included didanosine. Although the role of tenofovir in precipitating acute renal failure is unclear, progressive accumulation of the drug and pharmacologic interaction that caused increased levels of didanosine were the likely antecedents of increased mitochondrial toxicity that led to lactic acidosis.

Original languageEnglish (US)
Pages (from-to)1082-1085
Number of pages4
JournalClinical Infectious Diseases
Volume36
Issue number8
DOIs
StatePublished - Apr 15 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine'. Together they form a unique fingerprint.

  • Cite this