Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

Melissa D. Murphy, Mary O'Hearn, Sunwen Chou

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

We describe a 49-year-old man with human immunodeficiency virus infection and stable chronic renal insufficiency who developed acute oliguric renal failure and severe lactic acidosis and who died several weeks after tenofovir was added to an antiretroviral regimen that included didanosine. Although the role of tenofovir in precipitating acute renal failure is unclear, progressive accumulation of the drug and pharmacologic interaction that caused increased levels of didanosine were the likely antecedents of increased mitochondrial toxicity that led to lactic acidosis.

Original languageEnglish (US)
Pages (from-to)1082-1085
Number of pages4
JournalClinical Infectious Diseases
Volume36
Issue number8
DOIs
StatePublished - Apr 15 2003

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Tenofovir
Didanosine
Lactic Acidosis
Acute Kidney Injury
Virus Diseases
Chronic Renal Insufficiency
Drug Interactions
HIV

ASJC Scopus subject areas

  • Immunology

Cite this

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine. / Murphy, Melissa D.; O'Hearn, Mary; Chou, Sunwen.

In: Clinical Infectious Diseases, Vol. 36, No. 8, 15.04.2003, p. 1082-1085.

Research output: Contribution to journalArticle

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