Fatal cardiovascular collapse following acute colchicine ingestion

Michael E. Mullins, Emily A. Carrico, B. Zane Horowitz

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Background: A previously published prognostic rule predicts 100% survival after ingestion of colchicine doses less than 0.5 mg/kg and 100% mortality after ingestion of more than 0.8 mg/kg. This rule inaccurately predicted survival in a recent case. Case Report: We present a case of fatal colchicine poisoning in an adult who ingested a maximum of 39.6 mg of colchicine (0.40 mg/kg). He subsequently developed hypotension which was refractory to fluid resuscitation and infusion of vasopressors. He died of cardiovascular collapse approximately 35 hours after ingestion. Discussion: Fatal outcomes are possible even with colchicine doses less than 0.5 mg/kg. Physicians caring for colchicine-poisoned patients must be prepared for the possibility of acute cardiovascular collapse and ventricular dysrhythmias regardless of the reported dose of colchicine.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalJournal of Toxicology - Clinical Toxicology
Volume38
Issue number1
DOIs
StatePublished - Mar 4 2000

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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