Fatal ALK-negative systemic anaplastic large cell lymphoma presenting with disseminated cutaneous dome-shaped papules and nodules

Jayne Eleanor Bird, Justin John Leitenberger, Alvin Jr Solomon, Andrew Blauvelt, Robert Hopkins

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3 Citations (Scopus)

Abstract

Anaplastic large cell lymphoma (ALCL) is classified as a CD30 positive non-Hodgkin lymphoma. Systemic ALCL (S-ALCL) is further subdivided into two subgroups based on anaplastic lymphoma kinase (ALK) expression. In systemic ALCL, positive ALK expression correlates with a favorable prognosis, whereas negative ALK expression correlates with poorer overall survival. By definition, primary cutaneous ALCL (cut-ALCL) is limited to the skin and is uniformly ALK-negative. Cut-ALCL closely resembles LyP with regards to its benign clinical course and CD30 positivity. We describe a unique case of ALK-negative (ALK-) S-ALCL presenting with cutaneous disseminated dome-shaped papules.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume18
Issue number5
StatePublished - May 2012

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Anaplastic Large-Cell Lymphoma
Skin
Primary Cutaneous Anaplastic Large Cell Lymphoma
Non-Hodgkin's Lymphoma
anaplastic lymphoma kinase

ASJC Scopus subject areas

  • Dermatology

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Fatal ALK-negative systemic anaplastic large cell lymphoma presenting with disseminated cutaneous dome-shaped papules and nodules. / Bird, Jayne Eleanor; Leitenberger, Justin John; Solomon, Alvin Jr; Blauvelt, Andrew; Hopkins, Robert.

In: Dermatology Online Journal, Vol. 18, No. 5, 05.2012.

Research output: Contribution to journalArticle

Bird, Jayne Eleanor ; Leitenberger, Justin John ; Solomon, Alvin Jr ; Blauvelt, Andrew ; Hopkins, Robert. / Fatal ALK-negative systemic anaplastic large cell lymphoma presenting with disseminated cutaneous dome-shaped papules and nodules. In: Dermatology Online Journal. 2012 ; Vol. 18, No. 5.
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