Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report

Samantha Lau, Xiaomin Lu, Lyn Balsamo, Meenakshi Devidas, Naomi Winick, Stephen P. Hunger, William Carroll, Linda Stork, Kelly Maloney, Nina Kadan-Lottick

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18 Scopus citations

Abstract

Background: Despite higher cure rates, childhood acute lymphoblastic leukemia (ALL) may continue to result in considerable family strain. We sought to (i) measure incidence of divorce, reduced career opportunities, changes to work hours, home relocation, and changes to family planning at one year after ALL diagnosis; and (ii) Identify family and patient factors associated with these events. Procedure: We conducted a prospective cohort study of 159 children with average risk-ALL enrolled and treated on COG protocol AALL0331 at 31 selected sites. Eligibility criteria included age ≥2 years and English or Spanish comprehension. Parents completed surveys at three time points during the first 12 months of therapy. Results: Parents were at significantly increased risk of loss of employment (46% vs. 9.1%, P≤0.001) than peers nationally. 13% divorced/separated, 27% relocated homes, 22% decided not to have more children, 51% declined occupational opportunities, and 68% decreased work hours. In adjusted analyses, relocation correlated with less maternal education (OR: 4.27 [95% CI: 1.43-12.82]). Declining parental opportunities associated with family income

Original languageEnglish (US)
Pages (from-to)2277-2284
Number of pages8
JournalPediatric Blood and Cancer
Volume61
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

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Keywords

  • Family coping/functioning
  • Leukemia
  • Pediatric cancer

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Lau, S., Lu, X., Balsamo, L., Devidas, M., Winick, N., Hunger, S. P., ... Kadan-Lottick, N. (2014). Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report. Pediatric Blood and Cancer, 61(12), 2277-2284. https://doi.org/10.1002/pbc.25195