Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report

Samantha Lau, Xiaomin Lu, Lyn Balsamo, Meenakshi Devidas, Naomi Winick, Stephen P. Hunger, William Carroll, Linda Stork, Kelly Maloney, Nina Kadan-Lottick

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Despite higher cure rates, childhood acute lymphoblastic leukemia (ALL) may continue to result in considerable family strain. We sought to (i) measure incidence of divorce, reduced career opportunities, changes to work hours, home relocation, and changes to family planning at one year after ALL diagnosis; and (ii) Identify family and patient factors associated with these events. Procedure: We conducted a prospective cohort study of 159 children with average risk-ALL enrolled and treated on COG protocol AALL0331 at 31 selected sites. Eligibility criteria included age ≥2 years and English or Spanish comprehension. Parents completed surveys at three time points during the first 12 months of therapy. Results: Parents were at significantly increased risk of loss of employment (46% vs. 9.1%, P≤0.001) than peers nationally. 13% divorced/separated, 27% relocated homes, 22% decided not to have more children, 51% declined occupational opportunities, and 68% decreased work hours. In adjusted analyses, relocation correlated with less maternal education (OR: 4.27 [95% CI: 1.43-12.82]). Declining parental opportunities associated with family income

Original languageEnglish (US)
Pages (from-to)2277-2284
Number of pages8
JournalPediatric Blood and Cancer
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Divorce
Parents
Family Planning Services
Cohort Studies
Therapeutics
Mothers
Prospective Studies
Education
Incidence

Keywords

  • Family coping/functioning
  • Leukemia
  • Pediatric cancer

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Lau, S., Lu, X., Balsamo, L., Devidas, M., Winick, N., Hunger, S. P., ... Kadan-Lottick, N. (2014). Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report. Pediatric Blood and Cancer, 61(12), 2277-2284. https://doi.org/10.1002/pbc.25195

Family life events in the first year of acute lymphoblastic leukemia therapy : A children's oncology group report. / Lau, Samantha; Lu, Xiaomin; Balsamo, Lyn; Devidas, Meenakshi; Winick, Naomi; Hunger, Stephen P.; Carroll, William; Stork, Linda; Maloney, Kelly; Kadan-Lottick, Nina.

In: Pediatric Blood and Cancer, Vol. 61, No. 12, 01.12.2014, p. 2277-2284.

Research output: Contribution to journalArticle

Lau, S, Lu, X, Balsamo, L, Devidas, M, Winick, N, Hunger, SP, Carroll, W, Stork, L, Maloney, K & Kadan-Lottick, N 2014, 'Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report', Pediatric Blood and Cancer, vol. 61, no. 12, pp. 2277-2284. https://doi.org/10.1002/pbc.25195
Lau, Samantha ; Lu, Xiaomin ; Balsamo, Lyn ; Devidas, Meenakshi ; Winick, Naomi ; Hunger, Stephen P. ; Carroll, William ; Stork, Linda ; Maloney, Kelly ; Kadan-Lottick, Nina. / Family life events in the first year of acute lymphoblastic leukemia therapy : A children's oncology group report. In: Pediatric Blood and Cancer. 2014 ; Vol. 61, No. 12. pp. 2277-2284.
@article{1794586316ee4d60be0980f3dad101ee,
title = "Family life events in the first year of acute lymphoblastic leukemia therapy: A children's oncology group report",
abstract = "Background: Despite higher cure rates, childhood acute lymphoblastic leukemia (ALL) may continue to result in considerable family strain. We sought to (i) measure incidence of divorce, reduced career opportunities, changes to work hours, home relocation, and changes to family planning at one year after ALL diagnosis; and (ii) Identify family and patient factors associated with these events. Procedure: We conducted a prospective cohort study of 159 children with average risk-ALL enrolled and treated on COG protocol AALL0331 at 31 selected sites. Eligibility criteria included age ≥2 years and English or Spanish comprehension. Parents completed surveys at three time points during the first 12 months of therapy. Results: Parents were at significantly increased risk of loss of employment (46{\%} vs. 9.1{\%}, P≤0.001) than peers nationally. 13{\%} divorced/separated, 27{\%} relocated homes, 22{\%} decided not to have more children, 51{\%} declined occupational opportunities, and 68{\%} decreased work hours. In adjusted analyses, relocation correlated with less maternal education (OR: 4.27 [95{\%} CI: 1.43-12.82]). Declining parental opportunities associated with family income",
keywords = "Family coping/functioning, Leukemia, Pediatric cancer",
author = "Samantha Lau and Xiaomin Lu and Lyn Balsamo and Meenakshi Devidas and Naomi Winick and Hunger, {Stephen P.} and William Carroll and Linda Stork and Kelly Maloney and Nina Kadan-Lottick",
year = "2014",
month = "12",
day = "1",
doi = "10.1002/pbc.25195",
language = "English (US)",
volume = "61",
pages = "2277--2284",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "12",

}

TY - JOUR

T1 - Family life events in the first year of acute lymphoblastic leukemia therapy

T2 - A children's oncology group report

AU - Lau, Samantha

AU - Lu, Xiaomin

AU - Balsamo, Lyn

AU - Devidas, Meenakshi

AU - Winick, Naomi

AU - Hunger, Stephen P.

AU - Carroll, William

AU - Stork, Linda

AU - Maloney, Kelly

AU - Kadan-Lottick, Nina

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background: Despite higher cure rates, childhood acute lymphoblastic leukemia (ALL) may continue to result in considerable family strain. We sought to (i) measure incidence of divorce, reduced career opportunities, changes to work hours, home relocation, and changes to family planning at one year after ALL diagnosis; and (ii) Identify family and patient factors associated with these events. Procedure: We conducted a prospective cohort study of 159 children with average risk-ALL enrolled and treated on COG protocol AALL0331 at 31 selected sites. Eligibility criteria included age ≥2 years and English or Spanish comprehension. Parents completed surveys at three time points during the first 12 months of therapy. Results: Parents were at significantly increased risk of loss of employment (46% vs. 9.1%, P≤0.001) than peers nationally. 13% divorced/separated, 27% relocated homes, 22% decided not to have more children, 51% declined occupational opportunities, and 68% decreased work hours. In adjusted analyses, relocation correlated with less maternal education (OR: 4.27 [95% CI: 1.43-12.82]). Declining parental opportunities associated with family income

AB - Background: Despite higher cure rates, childhood acute lymphoblastic leukemia (ALL) may continue to result in considerable family strain. We sought to (i) measure incidence of divorce, reduced career opportunities, changes to work hours, home relocation, and changes to family planning at one year after ALL diagnosis; and (ii) Identify family and patient factors associated with these events. Procedure: We conducted a prospective cohort study of 159 children with average risk-ALL enrolled and treated on COG protocol AALL0331 at 31 selected sites. Eligibility criteria included age ≥2 years and English or Spanish comprehension. Parents completed surveys at three time points during the first 12 months of therapy. Results: Parents were at significantly increased risk of loss of employment (46% vs. 9.1%, P≤0.001) than peers nationally. 13% divorced/separated, 27% relocated homes, 22% decided not to have more children, 51% declined occupational opportunities, and 68% decreased work hours. In adjusted analyses, relocation correlated with less maternal education (OR: 4.27 [95% CI: 1.43-12.82]). Declining parental opportunities associated with family income

KW - Family coping/functioning

KW - Leukemia

KW - Pediatric cancer

UR - http://www.scopus.com/inward/record.url?scp=84911485590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911485590&partnerID=8YFLogxK

U2 - 10.1002/pbc.25195

DO - 10.1002/pbc.25195

M3 - Article

C2 - 25175168

AN - SCOPUS:84911485590

VL - 61

SP - 2277

EP - 2284

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 12

ER -