Family history of seizures in posttraumatic and alcohol-associated seizure disorders

B. A. Schaumann, J. F. Annegers, S. B. Johnson, K. J. Moore, M. F. Lubozynski, Martin Salinsky

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The potential role of genetic factors in the etiology of posttraumatic and alcohol-associated seizures was studied in 289 male patients with recurrent seizures and in 174 individuals who had never experienced a seizure. The incidence of seizures in first-degree relatives of probands was compared with that in relatives of unaffected individuals. Relatives of patients with alcohol-associated seizures had a rate ratio of 2.45 [95% confidence interval (CI) 1.41-4.25], whereas no excess incidence was noted among relatives of posttraumatic epilepsy patients (rate ratio 1.20, 0.64-2.25 CI). Relatives of probands with both antecedents showed an intermediate rate ratio of 1.72 (0.92-3.20 CI). Among probands with alcohol-associated seizures, the rate ratio of 2.05 for patients with alcohol-related seizures (i.e., spontaneously occurring seizures in association with chronic alcohol abuse) was slightly higher than that of 1.85 for probands with alcohol withdrawal seizures. Trauma severity had a slight impact on the incidence of affected relatives; patients with severe head injuries had a rate ratio of 0.73 and probands with milder trauma had a rate ratio of 0.99. The results indicate a limited, if any, role of genetic predisposition in development of posttraumatic seizures. Alcohol-related seizures, however, showed familial aggregation of unprovoked seizures, suggesting an involvement of genetic factors in the origin of such seizures.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalEpilepsia
Volume35
Issue number1
StatePublished - 1994

Fingerprint

Epilepsy
Seizures
Alcohols
Confidence Intervals
Alcohol Withdrawal Seizures
Incidence
Wounds and Injuries
Genetic Predisposition to Disease
Craniocerebral Trauma
Alcoholism

Keywords

  • Alcoholism
  • Genetics
  • Posttraumatic epilepsy
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schaumann, B. A., Annegers, J. F., Johnson, S. B., Moore, K. J., Lubozynski, M. F., & Salinsky, M. (1994). Family history of seizures in posttraumatic and alcohol-associated seizure disorders. Epilepsia, 35(1), 48-52.

Family history of seizures in posttraumatic and alcohol-associated seizure disorders. / Schaumann, B. A.; Annegers, J. F.; Johnson, S. B.; Moore, K. J.; Lubozynski, M. F.; Salinsky, Martin.

In: Epilepsia, Vol. 35, No. 1, 1994, p. 48-52.

Research output: Contribution to journalArticle

Schaumann, BA, Annegers, JF, Johnson, SB, Moore, KJ, Lubozynski, MF & Salinsky, M 1994, 'Family history of seizures in posttraumatic and alcohol-associated seizure disorders', Epilepsia, vol. 35, no. 1, pp. 48-52.
Schaumann BA, Annegers JF, Johnson SB, Moore KJ, Lubozynski MF, Salinsky M. Family history of seizures in posttraumatic and alcohol-associated seizure disorders. Epilepsia. 1994;35(1):48-52.
Schaumann, B. A. ; Annegers, J. F. ; Johnson, S. B. ; Moore, K. J. ; Lubozynski, M. F. ; Salinsky, Martin. / Family history of seizures in posttraumatic and alcohol-associated seizure disorders. In: Epilepsia. 1994 ; Vol. 35, No. 1. pp. 48-52.
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