Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma

Elizabeth T. Jacobs, Samir Gupta, John A. Baron, Amanda J. Cross, David Lieberman, Gwen Murphy, María Elena Martínez

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. Methods: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. Results: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05-1.53) or sibling (OR = 1.34; 95% CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. Conclusions: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume113
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Adenoma
Colorectal Neoplasms
Siblings
Colonoscopy
Fathers
Sample Size
Mothers
Prospective Studies

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. / Jacobs, Elizabeth T.; Gupta, Samir; Baron, John A.; Cross, Amanda J.; Lieberman, David; Murphy, Gwen; Martínez, María Elena.

In: American Journal of Gastroenterology, Vol. 113, No. 6, 01.06.2018, p. 899-905.

Research output: Contribution to journalArticle

Jacobs, Elizabeth T. ; Gupta, Samir ; Baron, John A. ; Cross, Amanda J. ; Lieberman, David ; Murphy, Gwen ; Martínez, María Elena. / Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. In: American Journal of Gastroenterology. 2018 ; Vol. 113, No. 6. pp. 899-905.
@article{d8e58296db7c46568629bc4f73f1e65d,
title = "Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma",
abstract = "Objectives: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. Methods: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. Results: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95{\%} CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95{\%} CI = 1.05-1.53) or sibling (OR = 1.34; 95{\%} CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95{\%} CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95{\%} CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. Conclusions: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.",
author = "Jacobs, {Elizabeth T.} and Samir Gupta and Baron, {John A.} and Cross, {Amanda J.} and David Lieberman and Gwen Murphy and Mart{\'i}nez, {Mar{\'i}a Elena}",
year = "2018",
month = "6",
day = "1",
doi = "10.1038/s41395-018-0007-x",
language = "English (US)",
volume = "113",
pages = "899--905",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma

AU - Jacobs, Elizabeth T.

AU - Gupta, Samir

AU - Baron, John A.

AU - Cross, Amanda J.

AU - Lieberman, David

AU - Murphy, Gwen

AU - Martínez, María Elena

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objectives: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. Methods: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. Results: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05-1.53) or sibling (OR = 1.34; 95% CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. Conclusions: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.

AB - Objectives: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. Methods: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. Results: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05-1.53) or sibling (OR = 1.34; 95% CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. Conclusions: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.

UR - http://www.scopus.com/inward/record.url?scp=85042233798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042233798&partnerID=8YFLogxK

U2 - 10.1038/s41395-018-0007-x

DO - 10.1038/s41395-018-0007-x

M3 - Article

C2 - 29463834

AN - SCOPUS:85042233798

VL - 113

SP - 899

EP - 905

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 6

ER -