Familial skin cancer syndromes Increased melanoma risk

Katherine J. Ransohoff; Prajaka D. Jaju; Jean Y. Tang; Michele Carbone; Sancy Leachman; Kavita Y. Sarin

doi:10.1016/j.jaad.2015.09.070

Familial skin cancer syndromes Increased melanoma risk

Katherine J. Ransohoff, Prajaka D. Jaju, Jean Y. Tang, Michele Carbone, Sancy Leachman, Kavita Y. Sarin

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

Original language	English (US)
Pages (from-to)	423-434
Number of pages	12
Journal	Journal of the American Academy of Dermatology
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/j.jaad.2015.09.070
State	Published - Mar 1 2016

Keywords

genetic syndromes
genetics
inherited cancer risk
melanoma
oncogenes
skin cancer
tumor suppressor

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2015.09.070

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title = "Familial skin cancer syndromes Increased melanoma risk",

abstract = "Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.",

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AU - Ransohoff, Katherine J.

AU - Jaju, Prajaka D.

AU - Tang, Jean Y.

AU - Carbone, Michele

AU - Leachman, Sancy

AU - Sarin, Kavita Y.

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AB - Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

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KW - genetics

KW - inherited cancer risk

KW - melanoma

KW - oncogenes

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KW - tumor suppressor

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Familial skin cancer syndromes Increased melanoma risk

Abstract

Keywords

ASJC Scopus subject areas

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