Familial skin cancer syndromes Increased melanoma risk

Katherine J. Ransohoff, Prajaka D. Jaju, Jean Y. Tang, Michele Carbone, Sancy Leachman, Kavita Y. Sarin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

Original languageEnglish (US)
Pages (from-to)423-434
Number of pages12
JournalJournal of the American Academy of Dermatology
Volume74
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Skin Neoplasms
Melanoma
Germ-Line Mutation
Genetic Counseling
Genetic Testing
Early Detection of Cancer
Hair
Genes
Neoplasms

Keywords

  • genetic syndromes
  • genetics
  • inherited cancer risk
  • melanoma
  • oncogenes
  • skin cancer
  • tumor suppressor

ASJC Scopus subject areas

  • Dermatology

Cite this

Familial skin cancer syndromes Increased melanoma risk. / Ransohoff, Katherine J.; Jaju, Prajaka D.; Tang, Jean Y.; Carbone, Michele; Leachman, Sancy; Sarin, Kavita Y.

In: Journal of the American Academy of Dermatology, Vol. 74, No. 3, 01.03.2016, p. 423-434.

Research output: Contribution to journalArticle

Ransohoff, Katherine J. ; Jaju, Prajaka D. ; Tang, Jean Y. ; Carbone, Michele ; Leachman, Sancy ; Sarin, Kavita Y. / Familial skin cancer syndromes Increased melanoma risk. In: Journal of the American Academy of Dermatology. 2016 ; Vol. 74, No. 3. pp. 423-434.
@article{4bff41d3878a4fe989150bc3c8859091,
title = "Familial skin cancer syndromes Increased melanoma risk",
abstract = "Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10{\%} of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.",
keywords = "genetic syndromes, genetics, inherited cancer risk, melanoma, oncogenes, skin cancer, tumor suppressor",
author = "Ransohoff, {Katherine J.} and Jaju, {Prajaka D.} and Tang, {Jean Y.} and Michele Carbone and Sancy Leachman and Sarin, {Kavita Y.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.jaad.2015.09.070",
language = "English (US)",
volume = "74",
pages = "423--434",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Familial skin cancer syndromes Increased melanoma risk

AU - Ransohoff, Katherine J.

AU - Jaju, Prajaka D.

AU - Tang, Jean Y.

AU - Carbone, Michele

AU - Leachman, Sancy

AU - Sarin, Kavita Y.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

AB - Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

KW - genetic syndromes

KW - genetics

KW - inherited cancer risk

KW - melanoma

KW - oncogenes

KW - skin cancer

KW - tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84958259441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958259441&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2015.09.070

DO - 10.1016/j.jaad.2015.09.070

M3 - Article

C2 - 26892652

AN - SCOPUS:84958259441

VL - 74

SP - 423

EP - 434

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -