Familial resemblance of bone mineralization, calcium intake, and physical activity in early-adolescent daughters, their mothers, and maternal grandmothers

Susan M. Runyan, Diane Stadler, Cynthia N. Bainbridge, Scott C. Miller, Laurie J. Moyer-Mileur

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective To describe familial relationships among bone mineral density (BMD), calcium intake, and physical activity in early-adolescent daughters, their premenopausal mothers, and postmenopausal maternal grandmothers. Subjects Healthy, early-adolescent daughter and premenopausal mother pairs (n=72) were enrolled in the study. In addition, a cohort of 22 postmenopausal maternal grandmothers were measured for comparison of related triads (n=22). Design Cross-sectional measurements of hip (three sites) and lumbar spine BMD by dual energy x-ray absorptiometry (DXA), body height and weight, menstrual function, current calcium intake, and current and past physical activity patterns were assessed using recalls and questionnaires. Statistical analysis Correlational analysis was used to establish relationships between bone characteristics and body size, menstrual function, calcium intake, and physical activity. Multiple regression analyses with backward elimination were used to examine heritability of bone characteristics in daughter-mother and mother-grandmother pairs and daughter-mother-grandmother triads. Quick cluster analysis and cross-tabulation with Pearson's χ2 were used to evaluate familial patterns for bone characteristics and lifestyle practices. Results Height, weight, and lumbar spine BMD were significantly correlated within mother-daughter pairs. Current and past calcium intakes were not related within pairs or triads or to BMD in the daughters or the grandmothers. A weak inverse relationship between calcium intake and the hip trochanter and lumbar spine BMD was observed in the mothers (R2=-0.25; P=.05). Physical activity, independent of calcium intake, was strong predictor of BMD for daughters and mothers. Among the daughters, the hertiability estimates for trochanter and lumbar spine BMD were 0.56 and 0.70, respectively (P2=0.66; P

Original languageEnglish (US)
Pages (from-to)1320-1325
Number of pages6
JournalJournal of the American Dietetic Association
Volume103
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

Fingerprint

Physiologic Calcification
bone mineralization
bone density
Nuclear Family
physical activity
lumbar spine
Mothers
Exercise
Calcium
Bone Density
calcium
Spine
bones
hips
Bone and Bones
Femur
Hip
Grandparents
lifestyle
cluster analysis

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

Cite this

Familial resemblance of bone mineralization, calcium intake, and physical activity in early-adolescent daughters, their mothers, and maternal grandmothers. / Runyan, Susan M.; Stadler, Diane; Bainbridge, Cynthia N.; Miller, Scott C.; Moyer-Mileur, Laurie J.

In: Journal of the American Dietetic Association, Vol. 103, No. 10, 10.2003, p. 1320-1325.

Research output: Contribution to journalArticle

@article{561f665bd8a3438db928bdec5798cb3a,
title = "Familial resemblance of bone mineralization, calcium intake, and physical activity in early-adolescent daughters, their mothers, and maternal grandmothers",
abstract = "Objective To describe familial relationships among bone mineral density (BMD), calcium intake, and physical activity in early-adolescent daughters, their premenopausal mothers, and postmenopausal maternal grandmothers. Subjects Healthy, early-adolescent daughter and premenopausal mother pairs (n=72) were enrolled in the study. In addition, a cohort of 22 postmenopausal maternal grandmothers were measured for comparison of related triads (n=22). Design Cross-sectional measurements of hip (three sites) and lumbar spine BMD by dual energy x-ray absorptiometry (DXA), body height and weight, menstrual function, current calcium intake, and current and past physical activity patterns were assessed using recalls and questionnaires. Statistical analysis Correlational analysis was used to establish relationships between bone characteristics and body size, menstrual function, calcium intake, and physical activity. Multiple regression analyses with backward elimination were used to examine heritability of bone characteristics in daughter-mother and mother-grandmother pairs and daughter-mother-grandmother triads. Quick cluster analysis and cross-tabulation with Pearson's χ2 were used to evaluate familial patterns for bone characteristics and lifestyle practices. Results Height, weight, and lumbar spine BMD were significantly correlated within mother-daughter pairs. Current and past calcium intakes were not related within pairs or triads or to BMD in the daughters or the grandmothers. A weak inverse relationship between calcium intake and the hip trochanter and lumbar spine BMD was observed in the mothers (R2=-0.25; P=.05). Physical activity, independent of calcium intake, was strong predictor of BMD for daughters and mothers. Among the daughters, the hertiability estimates for trochanter and lumbar spine BMD were 0.56 and 0.70, respectively (P2=0.66; P",
author = "Runyan, {Susan M.} and Diane Stadler and Bainbridge, {Cynthia N.} and Miller, {Scott C.} and Moyer-Mileur, {Laurie J.}",
year = "2003",
month = "10",
doi = "10.1016/S0002-8223(03)01075-7",
language = "English (US)",
volume = "103",
pages = "1320--1325",
journal = "Journal of the Academy of Nutrition and Dietetics",
issn = "2212-2672",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Familial resemblance of bone mineralization, calcium intake, and physical activity in early-adolescent daughters, their mothers, and maternal grandmothers

AU - Runyan, Susan M.

AU - Stadler, Diane

AU - Bainbridge, Cynthia N.

AU - Miller, Scott C.

AU - Moyer-Mileur, Laurie J.

PY - 2003/10

Y1 - 2003/10

N2 - Objective To describe familial relationships among bone mineral density (BMD), calcium intake, and physical activity in early-adolescent daughters, their premenopausal mothers, and postmenopausal maternal grandmothers. Subjects Healthy, early-adolescent daughter and premenopausal mother pairs (n=72) were enrolled in the study. In addition, a cohort of 22 postmenopausal maternal grandmothers were measured for comparison of related triads (n=22). Design Cross-sectional measurements of hip (three sites) and lumbar spine BMD by dual energy x-ray absorptiometry (DXA), body height and weight, menstrual function, current calcium intake, and current and past physical activity patterns were assessed using recalls and questionnaires. Statistical analysis Correlational analysis was used to establish relationships between bone characteristics and body size, menstrual function, calcium intake, and physical activity. Multiple regression analyses with backward elimination were used to examine heritability of bone characteristics in daughter-mother and mother-grandmother pairs and daughter-mother-grandmother triads. Quick cluster analysis and cross-tabulation with Pearson's χ2 were used to evaluate familial patterns for bone characteristics and lifestyle practices. Results Height, weight, and lumbar spine BMD were significantly correlated within mother-daughter pairs. Current and past calcium intakes were not related within pairs or triads or to BMD in the daughters or the grandmothers. A weak inverse relationship between calcium intake and the hip trochanter and lumbar spine BMD was observed in the mothers (R2=-0.25; P=.05). Physical activity, independent of calcium intake, was strong predictor of BMD for daughters and mothers. Among the daughters, the hertiability estimates for trochanter and lumbar spine BMD were 0.56 and 0.70, respectively (P2=0.66; P

AB - Objective To describe familial relationships among bone mineral density (BMD), calcium intake, and physical activity in early-adolescent daughters, their premenopausal mothers, and postmenopausal maternal grandmothers. Subjects Healthy, early-adolescent daughter and premenopausal mother pairs (n=72) were enrolled in the study. In addition, a cohort of 22 postmenopausal maternal grandmothers were measured for comparison of related triads (n=22). Design Cross-sectional measurements of hip (three sites) and lumbar spine BMD by dual energy x-ray absorptiometry (DXA), body height and weight, menstrual function, current calcium intake, and current and past physical activity patterns were assessed using recalls and questionnaires. Statistical analysis Correlational analysis was used to establish relationships between bone characteristics and body size, menstrual function, calcium intake, and physical activity. Multiple regression analyses with backward elimination were used to examine heritability of bone characteristics in daughter-mother and mother-grandmother pairs and daughter-mother-grandmother triads. Quick cluster analysis and cross-tabulation with Pearson's χ2 were used to evaluate familial patterns for bone characteristics and lifestyle practices. Results Height, weight, and lumbar spine BMD were significantly correlated within mother-daughter pairs. Current and past calcium intakes were not related within pairs or triads or to BMD in the daughters or the grandmothers. A weak inverse relationship between calcium intake and the hip trochanter and lumbar spine BMD was observed in the mothers (R2=-0.25; P=.05). Physical activity, independent of calcium intake, was strong predictor of BMD for daughters and mothers. Among the daughters, the hertiability estimates for trochanter and lumbar spine BMD were 0.56 and 0.70, respectively (P2=0.66; P

UR - http://www.scopus.com/inward/record.url?scp=0242304417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242304417&partnerID=8YFLogxK

U2 - 10.1016/S0002-8223(03)01075-7

DO - 10.1016/S0002-8223(03)01075-7

M3 - Article

C2 - 14520251

AN - SCOPUS:0242304417

VL - 103

SP - 1320

EP - 1325

JO - Journal of the Academy of Nutrition and Dietetics

JF - Journal of the Academy of Nutrition and Dietetics

SN - 2212-2672

IS - 10

ER -