Familial giant cell arteritis: Report of an HLA-typed sibling pair and a review of the literature

R. Wernick, M. Davey, P. Bonafede

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalClinical and experimental rheumatology
Volume12
Issue number1
StatePublished - Jan 1 1994

Keywords

  • HLA antigens
  • giant cell arteritis
  • temporal arteritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Familial giant cell arteritis: Report of an HLA-typed sibling pair and a review of the literature'. Together they form a unique fingerprint.

  • Cite this