Familial giant cell arteritis

Report of an HLA-typed sibling pair and a review of the literature

R. Wernick, Michael Davey, P. Bonafede

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalClinical and Experimental Rheumatology
Volume12
Issue number1
StatePublished - 1994
Externally publishedYes

Fingerprint

Giant Cell Arteritis
Haplotypes
Alleles
Biopsy
HLA-DRB1*04 antigen

Keywords

  • giant cell arteritis
  • HLA antigens
  • temporal arteritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Familial giant cell arteritis : Report of an HLA-typed sibling pair and a review of the literature. / Wernick, R.; Davey, Michael; Bonafede, P.

In: Clinical and Experimental Rheumatology, Vol. 12, No. 1, 1994, p. 63-66.

Research output: Contribution to journalArticle

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