Familial giant cell arteritis: Report of an HLA-typed sibling pair and a review of the literature

R. Wernick; M. Davey; P. Bonafede

Familial giant cell arteritis: Report of an HLA-typed sibling pair and a review of the literature

R. Wernick, M. Davey, P. Bonafede

Research output: Contribution to journal › Article › peer-review

Abstract

We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.

Original language	English (US)
Pages (from-to)	63-66
Number of pages	4
Journal	Clinical and experimental rheumatology
Volume	12
Issue number	1
State	Published - 1994
Externally published	Yes

Keywords

HLA antigens
giant cell arteritis
temporal arteritis

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

Cite this

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abstract = "We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.",

keywords = "HLA antigens, giant cell arteritis, temporal arteritis",

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AU - Bonafede, P.

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N2 - We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.

AB - We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.

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KW - temporal arteritis

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Familial giant cell arteritis: Report of an HLA-typed sibling pair and a review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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