Falsely low parathyroid hormone secondary to biotin interference: A case series

Abhijeet Waghray, Kresimira Milas, Kavita Nyalakonda, Allan E. Siperstein

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To present a case series on biotin interference in parathyroid hormone (PTH) level measurement.Methods: We revie. The presentation and management of patients at our institution evaluated for unexpectedly low PTH levels while taking biotin supplements i. The setting of high or normal serum calcium.Results: Two patients presented with surprising low parathyroid levels - one during preoperative evaluation for hyperparathyroidism and another during postoperative follow-up after subtotal parathyroidectomy. The patients were found to be taking 1,500 mcg and 5,000 mcg of biotin per day, respectively. The role of biotin interference was confirmed in one o. The patients when she was retested off biotin, and PTH levels responded appropriately. Biotin supplements remain as unbound molecules i. The serum, thus interfering with PTH enzyme-linked immunosorbent assay (ELISA) results and falsely depressin. The PTH level.Conclusion: Biotin supplement use has expanded ove. The years, ranging from medically endorsed therapies to home remedies. Review o. The 2 ELISA systems used at our institution demonstrates that free biotin mimic. The biotinylated antibody used i. The detection process. Screening for biotin use prior to PTH measurement and automatic biotin levels for clinically aberrant PTH levels provid. The clinician with a true PTH level - lowerin. The disease burden of untreated hyperparathyroidism while avoiding unnecessary work-ups for other processes.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalEndocrine Practice
Volume19
Issue number3
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Biotin
Parathyroid Hormone
Hyperparathyroidism
Enzyme-Linked Immunosorbent Assay
Hexamethonium
Parathyroidectomy
Traditional Medicine
Serum
Calcium
Antibodies

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Waghray, A., Milas, K., Nyalakonda, K., & Siperstein, A. E. (2013). Falsely low parathyroid hormone secondary to biotin interference: A case series. Endocrine Practice, 19(3), 451-455. https://doi.org/10.4158/EP12158.OR

Falsely low parathyroid hormone secondary to biotin interference : A case series. / Waghray, Abhijeet; Milas, Kresimira; Nyalakonda, Kavita; Siperstein, Allan E.

In: Endocrine Practice, Vol. 19, No. 3, 01.05.2013, p. 451-455.

Research output: Contribution to journalArticle

Waghray, A, Milas, K, Nyalakonda, K & Siperstein, AE 2013, 'Falsely low parathyroid hormone secondary to biotin interference: A case series', Endocrine Practice, vol. 19, no. 3, pp. 451-455. https://doi.org/10.4158/EP12158.OR
Waghray, Abhijeet ; Milas, Kresimira ; Nyalakonda, Kavita ; Siperstein, Allan E. / Falsely low parathyroid hormone secondary to biotin interference : A case series. In: Endocrine Practice. 2013 ; Vol. 19, No. 3. pp. 451-455.
@article{0904dc8b7e22441489d1c32c76b4c701,
title = "Falsely low parathyroid hormone secondary to biotin interference: A case series",
abstract = "Objective: To present a case series on biotin interference in parathyroid hormone (PTH) level measurement.Methods: We revie. The presentation and management of patients at our institution evaluated for unexpectedly low PTH levels while taking biotin supplements i. The setting of high or normal serum calcium.Results: Two patients presented with surprising low parathyroid levels - one during preoperative evaluation for hyperparathyroidism and another during postoperative follow-up after subtotal parathyroidectomy. The patients were found to be taking 1,500 mcg and 5,000 mcg of biotin per day, respectively. The role of biotin interference was confirmed in one o. The patients when she was retested off biotin, and PTH levels responded appropriately. Biotin supplements remain as unbound molecules i. The serum, thus interfering with PTH enzyme-linked immunosorbent assay (ELISA) results and falsely depressin. The PTH level.Conclusion: Biotin supplement use has expanded ove. The years, ranging from medically endorsed therapies to home remedies. Review o. The 2 ELISA systems used at our institution demonstrates that free biotin mimic. The biotinylated antibody used i. The detection process. Screening for biotin use prior to PTH measurement and automatic biotin levels for clinically aberrant PTH levels provid. The clinician with a true PTH level - lowerin. The disease burden of untreated hyperparathyroidism while avoiding unnecessary work-ups for other processes.",
author = "Abhijeet Waghray and Kresimira Milas and Kavita Nyalakonda and Siperstein, {Allan E.}",
year = "2013",
month = "5",
day = "1",
doi = "10.4158/EP12158.OR",
language = "English (US)",
volume = "19",
pages = "451--455",
journal = "Endocrine Practice",
issn = "1530-891X",
publisher = "American Association of Clinical Endocrinology",
number = "3",

}

TY - JOUR

T1 - Falsely low parathyroid hormone secondary to biotin interference

T2 - A case series

AU - Waghray, Abhijeet

AU - Milas, Kresimira

AU - Nyalakonda, Kavita

AU - Siperstein, Allan E.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Objective: To present a case series on biotin interference in parathyroid hormone (PTH) level measurement.Methods: We revie. The presentation and management of patients at our institution evaluated for unexpectedly low PTH levels while taking biotin supplements i. The setting of high or normal serum calcium.Results: Two patients presented with surprising low parathyroid levels - one during preoperative evaluation for hyperparathyroidism and another during postoperative follow-up after subtotal parathyroidectomy. The patients were found to be taking 1,500 mcg and 5,000 mcg of biotin per day, respectively. The role of biotin interference was confirmed in one o. The patients when she was retested off biotin, and PTH levels responded appropriately. Biotin supplements remain as unbound molecules i. The serum, thus interfering with PTH enzyme-linked immunosorbent assay (ELISA) results and falsely depressin. The PTH level.Conclusion: Biotin supplement use has expanded ove. The years, ranging from medically endorsed therapies to home remedies. Review o. The 2 ELISA systems used at our institution demonstrates that free biotin mimic. The biotinylated antibody used i. The detection process. Screening for biotin use prior to PTH measurement and automatic biotin levels for clinically aberrant PTH levels provid. The clinician with a true PTH level - lowerin. The disease burden of untreated hyperparathyroidism while avoiding unnecessary work-ups for other processes.

AB - Objective: To present a case series on biotin interference in parathyroid hormone (PTH) level measurement.Methods: We revie. The presentation and management of patients at our institution evaluated for unexpectedly low PTH levels while taking biotin supplements i. The setting of high or normal serum calcium.Results: Two patients presented with surprising low parathyroid levels - one during preoperative evaluation for hyperparathyroidism and another during postoperative follow-up after subtotal parathyroidectomy. The patients were found to be taking 1,500 mcg and 5,000 mcg of biotin per day, respectively. The role of biotin interference was confirmed in one o. The patients when she was retested off biotin, and PTH levels responded appropriately. Biotin supplements remain as unbound molecules i. The serum, thus interfering with PTH enzyme-linked immunosorbent assay (ELISA) results and falsely depressin. The PTH level.Conclusion: Biotin supplement use has expanded ove. The years, ranging from medically endorsed therapies to home remedies. Review o. The 2 ELISA systems used at our institution demonstrates that free biotin mimic. The biotinylated antibody used i. The detection process. Screening for biotin use prior to PTH measurement and automatic biotin levels for clinically aberrant PTH levels provid. The clinician with a true PTH level - lowerin. The disease burden of untreated hyperparathyroidism while avoiding unnecessary work-ups for other processes.

UR - http://www.scopus.com/inward/record.url?scp=84880107096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880107096&partnerID=8YFLogxK

U2 - 10.4158/EP12158.OR

DO - 10.4158/EP12158.OR

M3 - Article

C2 - 23337137

AN - SCOPUS:84880107096

VL - 19

SP - 451

EP - 455

JO - Endocrine Practice

JF - Endocrine Practice

SN - 1530-891X

IS - 3

ER -