Failure of nimodipine to improve neurologic outcome after eighteen minutes of cardiac arrest in the cat

Akio Tateishi, Mark S. Scheller, John C. Drummond, Mark H. Zornow, Marjorie R. Grafe, Jerry E. Fleischer, Harvey M. Shapiro

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The calcium entry blocker nimodipine was administered to cats following resuscitation from 18 min of cardiac arrest to evaluate its effect on neurologic and neuropathologic outcome in a clinically relevant model of complete cerebral ischemia. Cardiac arrest (ventricular fibrillation) was maintained for 18 min and resuscitation was performed by a standardized protocol in 40 cats. Beginning at 5 min post-resuscitation, nimodipine, 10 μg/kg over 2 min followed by 1 μg/kg per min for 10 h, or the same volume of placebo was administered in a randomized, blinded fashion. Neurologic deficits were scored at 2, 4, and 7 days post-resuscitation by observers blinded to the treatment group. Thirty cats were evaluated neurologically at 7 days post-resuscitation and were entered into data analysis (n = 15 per group). Neither neurologic deficit scores nor neuropathologic scores were significantly different between groups. The authors conclude that nimodipine administration in the manner and doses stated does not improve neurologic outcome in cats following resuscitation from cardiac arrest.

Original languageEnglish (US)
Pages (from-to)191-206
Number of pages16
JournalResuscitation
Volume21
Issue number2-3
DOIs
StatePublished - Apr 1991

Keywords

  • Calcium entry blocker
  • Cardiac arrest
  • Cats
  • Cerebral ischemia
  • Cerebral protection
  • Nimodipine

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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