Abstract
The calcium entry blocker nimodipine was administered to cats following resuscitation from 18 min of cardiac arrest to evaluate its effect on neurologic and neuropathologic outcome in a clinically relevant model of complete cerebral ischemia. Cardiac arrest (ventricular fibrillation) was maintained for 18 min and resuscitation was performed by a standardized protocol in 40 cats. Beginning at 5 min post-resuscitation, nimodipine, 10 μg/kg over 2 min followed by 1 μg/kg per min for 10 h, or the same volume of placebo was administered in a randomized, blinded fashion. Neurologic deficits were scored at 2, 4, and 7 days post-resuscitation by observers blinded to the treatment group. Thirty cats were evaluated neurologically at 7 days post-resuscitation and were entered into data analysis (n = 15 per group). Neither neurologic deficit scores nor neuropathologic scores were significantly different between groups. The authors conclude that nimodipine administration in the manner and doses stated does not improve neurologic outcome in cats following resuscitation from cardiac arrest.
Original language | English (US) |
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Pages (from-to) | 191-206 |
Number of pages | 16 |
Journal | Resuscitation |
Volume | 21 |
Issue number | 2-3 |
DOIs | |
State | Published - Apr 1991 |
Externally published | Yes |
Keywords
- Calcium entry blocker
- Cardiac arrest
- Cats
- Cerebral ischemia
- Cerebral protection
- Nimodipine
ASJC Scopus subject areas
- Emergency Medicine
- Emergency
- Cardiology and Cardiovascular Medicine