Failure of bronchial lavage to detect elevated levels of adrenocorticotropin (ACTH) in patients with acth-producing bronchial carcinoids

John L. Doppman, Harvey I. Pass, Lynnette Nieman, Gordon B. Cutler, George P. Chrousos, D. Lynn Loriaux

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Saline lavage of the major bronchial segments was performed in five patients immediately preceding lobectomy to remove an ACTH-producing bronchial carcinoid. Lavage fluid from each bronchus was concentrated, and ACTH determinations were performed. Elevated concentrations of ACTH were not demonstrated in the aspirate from the bronchus containing the known tumor. Two additional patients with ectopic ACTH syndrome from an unknown primary source also underwent selective segmental bronchial lavage for ACTH determination. Neither patient demonstrated ACTH gradients in the lavage specimens. One was found to have an ACTH-producing bronchial carcinoid 18 months after negative lavage. Selective segmental bronchoscopic lavage with measurement of ACTH levels on the aspirate is not an effective technique for detecting ACTH-producing bronchial carcinoid tumor.

Original languageEnglish (US)
Pages (from-to)1302-1304
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume69
Issue number6
DOIs
StatePublished - Dec 1989

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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