Factors that Determine the in vivo Dose-Response Relationship for Stable Chromosome Aberrations in A-Bomb Survivors

Akio A. Awa, Mimako Nakano, Kazuo Ohtaki, Yoshiaki Kodama, Joe Lucas, Joe Gray

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Computer programs have recently been developed to enable automatic detection of dicentric chromosomes on microscope slides. Theoretical calculations based on the probable limits of resolution of such a system suggested that about two thirds of dicentrics might be detectable. We present here some preliminary results from an ongoing evaluation of an automatic dicentric hunter using slides of lymphocyte preparations which have also been examined by eye. The data indicate an efficiency approaching 40% in dicentric detection.

Original languageEnglish (US)
Pages (from-to)206-214
Number of pages9
JournalJournal of radiation research
Volume33
DOIs
StatePublished - Jan 1 1992

Keywords

  • Stable chromosome aberrations
  • relationship/ frequencies survivors

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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