Abstract
Purpose To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. Design Cohort study using randomized controlled trial data. Methods Multicenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA. Results Baseline factors significantly associated with reduced BCVA included age ≥50 vs <50 years; posterior vs intermediate uveitis; uveitis duration >10 vs <6 years; anterior chamber (AC) flare >grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P =.52) and 10 letters (P <.001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs <6 years), incident AC flare, cataract at both baseline and follow-up, pseudophakia at baseline, persistence or incidence of vitreous haze, and incidence of macular thickening. Conclusions Intermediate, posterior, and panuveitis have a similarly favorable prognosis with both systemic and fluocinolone acetonide implant treatment. Eyes with more prolonged/severe inflammatory damage and/or inflammatory findings initially or during follow-up have a worse visual acuity prognosis. The results indicate the value of implementing best practices in managing inflammation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1133-1141.e9 |
| Journal | American journal of ophthalmology |
| Volume | 160 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2015 |
ASJC Scopus subject areas
- Ophthalmology
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In: American journal of ophthalmology, Vol. 160, No. 6, 2015, p. 1133-1141.e9.
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}
TY - JOUR
T1 - Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis
T2 - The Multicenter Uveitis Steroid Treatment (MUST) Trial
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AU - Altaweel, Michael M.
AU - Dunn, James P.
AU - Jabs, Douglas A.
AU - Lightman, Susan L.
AU - Thorne, Jennifer E.
AU - Holbrook, Janet T.
AU - Jaffe, Glenn J.
AU - Branchaud, Brenda
AU - Hahn, Paul
AU - Koreen, Larry
AU - Lad, Eleonora M.
AU - Lin, Phoebe
AU - Martel, Joseph Nissim
AU - Serrano, Neha
AU - Skalak, Cindy
AU - Vajzovic, Lejla
AU - Baer, Claxton
AU - Bryant, Joyce
AU - Chavala, Sai
AU - Cusick, Michael
AU - Day, Shelley
AU - Dayani, Pouya
AU - Ehlers, Justis
AU - Kesen, Muge
AU - Lee, Annie
AU - Melamud, Alex
AU - Qureshi, Jawad A.
AU - Scott, Adrienne Williams
AU - See, Robert F.
AU - Shuler, Robert K.
AU - Wood, Megan
AU - Yeh, Steven
AU - Fernandes, Alcides
AU - Gibbs, Deborah
AU - Leef, Donna
AU - Martin, Daniel F.
AU - Srivastava, Sunil
AU - Begum, Hosne
AU - Boring, Jeff
AU - Brotherson, Kristen L.
AU - Burkholder, Bryn
AU - Butler, Nicholas J.
AU - Cain, Dennis
AU - Cook, Mary A.
AU - Emmert, David
AU - Graul, Janis R.
AU - Herring, Mark
AU - Laing, Ashley
AU - Leung, Theresa G.
AU - Mahon, Michael C.
AU - Moradi, Ahmafreza
AU - Nwankwo, Antonia
AU - Ostheimer, Trucian L.
AU - Reed, Terry
AU - Arnold, Ellen
AU - Barnabie, Patricia M.
AU - Belair, Marie Lynn
AU - Bolton, Stephen G.
AU - Brodine, Joseph B.
AU - Brown, Diane M.
AU - Brune, Lisa M.
AU - Galor, Anat
AU - Gan, Theresa
AU - Jacobowitz, Adam
AU - Kapoor, Meera
AU - Kedhar, Sanjay
AU - Kim, Stephen
AU - Leder, Henry A.
AU - Livingston, Alison G.
AU - Morton, Yavette
AU - Nolan, Kisten
AU - Peters, George B.
AU - Soto, Priscilla
AU - Stevenson, Ricardo
AU - Tarver-Carr, Michelle
AU - Wang, Yue
AU - Foster, C. Stephen
AU - Anesi, Stephen D.
AU - Bruner, Linda
AU - Ceron, Olga
AU - Hinkle, David M.
AU - Persons, Nancy
AU - Wentworth, Bailey
AU - Acevedo, Sarah
AU - Anzaar, Fahd
AU - Cesca, Tom
AU - Contero, Angelica
AU - Fitzpatrick, Kayleigh
AU - Goronga, Faith
AU - Johnson, Jyothir
AU - Lebron, Karina Q.
AU - Marvell, Danielle
AU - Morgan, Chandra
AU - Patel, Nita
AU - Pinto, Jennifer
AU - Siddique, Sana S.
AU - Sprague, Janet
AU - Yilmaz, Taygan
AU - Sen, H. Nida
AU - Bono, Michael
AU - Cunningham, Denise
AU - Hayes, Darryl
AU - Koutsandreas, Dessie
AU - Nussenblatt, Robert B.
AU - Sherry, Patti R.
AU - Short, Gregory L.
AU - Smith, Wendy
AU - Temple, Alana
AU - Bamji, Allison
AU - Coleman, Hanna
AU - Davuluri, Geetaniali
AU - Faia, Lisa
AU - Gottlieb, Chloe
AU - Jirawuthiworavong, Guy V.
AU - Lew, Julie C.
AU - Mercer, Richard
AU - Obiyor, Dominic
AU - Perry, Cheryl H.
AU - Potapova, Natalia
AU - Weichel, Eric
AU - Wroblewski, Keith J.
AU - Latkany, Paul A.
AU - Coonan, Corinne
AU - Honda, Andrea
AU - Lorenzo-Latkany, Monica
AU - Masini, Robert
AU - Morell, Susan
AU - Nguyen, Angela
AU - Badamo, Jason
AU - Boyd, Kenneth M.
AU - Enos, Matthew
AU - Gallardo, Jenny
AU - Jarczynski, Jacek
AU - Lee, Ji Yun
AU - McGrosky, Mirjana
AU - Nour, Ann
AU - Sanchez, Meredith
AU - Steinberg, Kate
AU - Stawell, Richard J.
AU - Breayley, Lisa
AU - D'Sylva, Carly
AU - Glatz, Elizabeth
AU - Hodgson, Lauren
AU - Lim, Lyndell
AU - Ling, Cecilia
AU - McIntosh, Rachel
AU - Morrison, Julie
AU - Newton, Andrew
AU - Sanmugasundram, Sutha
AU - Smallwood, Richard
AU - Zamir, Ehud
AU - Hunt, Nicola
AU - Jones, Lisa
AU - Koukouras, Ignatios
AU - Williams, Suzanne
AU - Merrill, Pauline T.
AU - Carns, Danielle
AU - Richine, Len
AU - Voskuil-Marre, Denise L.
AU - Woo, Kisung
AU - Gaynes, Bruce
AU - Giannoulis, Christina
AU - Hulvey, Pam
AU - Kernbauer, Elaine
AU - Khan, Heena S.
AU - Levine, Sarah J.
AU - Toennessen, Scott
AU - Tonner, Eileen
AU - Wang, Robert C.
AU - Aguado, Hank
AU - Arceneaux, Sally
AU - Duignan, Karen
AU - Fish, Gary E.
AU - Hesse, Nick
AU - Jaramillo, Diana
AU - Mackens, Michael
AU - Arnwine, Jean
AU - Callanan, David
AU - Cummings, Kimberly
AU - Gray, Keith
AU - Howden, Susie
AU - Mutz, Karin
AU - Sanchez, Brenda
AU - Ismetova, Filis
AU - Prytherch, Ashley
AU - Seguin-Greenstein, Sophie
AU - Tomkins, Oren
AU - Bar, Asat
AU - Edwards, Kate
AU - Joshi, Lavanish
AU - Moraji, Jiten
AU - Samy, Ahmed
AU - Stubbs, Timothy
AU - Taylor, Simon
AU - Towler, Hamish
AU - Tronnberg, Rebecca
AU - Holland, Gary N.
AU - Almanzor, Robert D.
AU - Castellanos, Jose
AU - Hubschman, Jean Pierre
AU - Johiro, Ann K.
AU - Kukuyev, Alla
AU - Levinson, Ralph D.
AU - McCannel, Colin A.
AU - Ransome, Susan S.
AU - Gonzales, Christine R.
AU - Gupta, Anurag
AU - Kalyani, Partho S.
AU - Kapamajian, Michael A.
AU - Kappel, Peter J.
AU - Arcinue, Cheryl
AU - Chuang, Janne
AU - Barteselli, Giulio
AU - Currie, Glenn
AU - Mendoza, Veronica
AU - Powell, Debbie
AU - Clark, Tom
AU - Cochran, Denine E.
AU - Freeman, William R.
AU - Hedaya, Joshua
AU - Kemper, Tiara
AU - Kozak, Igor
AU - Lemoine, Jacqueline M.
AU - Loughran, Megan E.
AU - Magana, Luzandra
AU - Mojana, Francesca
AU - Morrison, Victoria
AU - Nguyen, Vivian
AU - Oster, Stephen F.
AU - Acharya, Nisha
AU - Clay, David
AU - Lee, Salena
AU - Lew, Mary
AU - Margolis, Todd P.
AU - Stewart, Jay
AU - Wong, Ira G.
AU - Brown, Debra
AU - Khouri, Claire M.
AU - Goldstein, Debra A.
AU - Birnbaum, Andrea
AU - Degillio, Andrea
AU - Rosa, Gemma De La
AU - Ramirez, Carmen
AU - Simjanowski, Evica
AU - Skelly, Mariner
AU - Castro-Malek, Anna L.
AU - Crooke, Catherine E.
AU - Huntley, Melody
AU - Nash, Katrina
AU - Niec, Marcia
AU - Pyatetsky, Dimitry
AU - Ramirez, Misel
AU - Rozenbajgier, Zuzanna
AU - Tessler, Howard H.
AU - Davis, Janet L.
AU - Albini, Thomas A.
AU - Chin, Marie
AU - Castaño, Daniela
AU - Elizondo, Ariana
AU - Ho, Macy
AU - Kovach, Jaclyn L.
AU - Lin, Richard C.S.
AU - Mandelcorn, Efrem
AU - Nguyen, Jackie K.D.
AU - Pacini, Aura
AU - Pineda, Susan
AU - Pinto, David A.
AU - Rebimbas, Jose
AU - Stepien, Kimberly E.
AU - Teran, Claudia
AU - Elner, Susan G.
AU - Bernard, Hillary
AU - Fournier, Linda
AU - Godsey, Lindsay
AU - Goings, Linda
AU - Hackel, Richard
AU - Hesselgrave, Moella
AU - Jayasundera, K. Thiran
AU - Prusak, Robert
AU - Titus, Pamela
AU - Bergeron, Melissa
AU - Blosser, Reneé
AU - Brown, Rebecca
AU - Chrisman-Mcclure, Carrie
AU - Gothrup, Julie R.
AU - Saxe, Stephen J.
AU - Sizemore, Deanna
AU - Berger, James
AU - Drossner, Sheri
AU - Dupont, Joan C.
AU - Maguire, Albert M.
AU - Petner, Janice
AU - Engelhard, Stephanie
AU - Hopkins, Tim
AU - Lo, Jonathan
AU - McCall, Dawn
AU - McRay, Monique
AU - Salvo, Rebecca
AU - Will, Daniel
AU - Xu, Wei
AU - Windsor, Elizabeth
AU - Weeney, Laurel
AU - Pavan, Peter R.
AU - Albritton, Ken
AU - Leto, Joann
AU - Madow, Brian
AU - Mayor, Lori
AU - Pautler, Scott E.
AU - Saxon, Wyatt
AU - Soto, Judy
AU - Goldstein, Burton
AU - Klukoff, Amy
AU - Lambright, Lucy
AU - McDonald, Kim
AU - Ortiz, Maria
AU - Scymanky, Susan
AU - Szalay, Dee Dee
AU - Rao, Narsing
AU - Davis, Tamara
AU - Douglass, Jackie
AU - Linton, Judith
AU - Padilla, Margaret
AU - Ramos, Sylvia
AU - Rao, Narsing A.
AU - Aguirre, Alexia
AU - Chong, Lawrence
AU - Cisneros, Lupe
AU - Corona, Elizabeth
AU - Eliott, Dean
AU - Fawzi, Amani
AU - Garcia, Jesse
AU - Khurana, Rahul
AU - Lim, Jennifer
AU - Mead, Rachel
AU - Tsai, Julie H.
AU - Vitale, Albert
AU - Bernstein, Paul S.
AU - Carlstrom, Bonnie
AU - Gilman, James
AU - Hanseen, Sandra
AU - Morris, Paula
AU - Ramirez, Diana
AU - Wegner, Kimberley
AU - Sheppard, John D.
AU - Anthony, Brianne
AU - Casper, Amber
AU - Felix-Kent, Lisa
AU - Fernandez, Jeanette
AU - Johnson, Tari
AU - Scoper, Stephen V.
AU - Cole, R. Denise
AU - Crawford, Nancy
AU - Franklin, Lisa
AU - Hamelin, Krista
AU - Martin, Jen
AU - Marx, Rebecca
AU - Schultz, Gregory
AU - Webb, Joseph
AU - Yeager, Pamela
AU - Kim, Rosa Y.
AU - Benz, Matthew S.
AU - Brown, David M.
AU - Chen, Eric
AU - Fish, Richard H.
AU - Kegley, Eric
AU - Shawver, Laura
AU - Wong, Tien P.
AU - De La Garza, Rebecca
AU - Friday, Shayla
AU - Rao, P. Kumar
AU - Adcock, Eve
AU - Apte, Rajendra S.
AU - Baladenski, Amy
AU - Curtis, Rhonda
AU - Gould, Sarah
AU - Hebden, Amanda
AU - Kambarian, Jamie
AU - Meyer, Charla
AU - Pistorius, Sam
AU - Quinn, Melanie
AU - Rathert, Greg
AU - Blinder, Kevin J.
AU - Hartz, Ashley
AU - Light, Pam
AU - Shah, Gaurav K.
AU - Vangelder, Russell
AU - Kurinij, Natalie
AU - Prusakowski, Nancy
AU - Hubbard, Larry
AU - Wittes, Janet
AU - Barlow, William E.
AU - Hochberg, Marc
AU - Lyon, Alice T.
AU - Palestine, Alan G.
AU - Simon, Lee S.
AU - Rosenbaum, James T.
AU - Smith, Harmon
AU - Acharya, Nisha R.
AU - Boring, Jeffrey A.
AU - Alexander, Judith
AU - Friedman, David S.
AU - Adler, Anna
AU - Burke, Alyce
AU - Katz, Joanne
AU - Reed, Susan
AU - Ansari, Husam
AU - Cohen, Nicholas
AU - Modak, Sanjukta
AU - Ng, Wai Ping
AU - Sugar, Elizabeth A.
AU - Burke, Alyce E.
AU - Drye, Lea T.
AU - Frick, Kevin D.
AU - Louis, Thomas A.
AU - Shade, Dave M.
AU - Pascual, Karen
AU - Slutsky-Sanon, Jill S.
AU - Allen, Amanda
AU - Glomp, Colby
AU - Hilal, Yasmin
AU - Nieves, Melissa A.
AU - Stevens, Maria
AU - Abreu, Francis
AU - Casper, Anne Shanklin
AU - Ewing, Cathleen
AU - Hart, Adante
AU - Lears, Andrea
AU - Li, Shirley
AU - Meinert, Jill
AU - Morrison, Vinnette
AU - Nowakowski, Deborah
AU - Reyes, Girlie
AU - Smith, Jacqueline
AU - Steuernagle, Karen
AU - Venugopal, Vidya
AU - Yu, Tsung
AU - Chen, Paul
AU - Collins, Karen
AU - Dodge, John
AU - Jackson, Rosetta
AU - Jimenez, Christian
AU - Landers, Ariel
AU - Livingston, Hope
AU - Meinert, Curtis L.
AU - Rayapudi, Sobharani
AU - Shen, Weijiang
AU - Shiflett, Charles
AU - Smith, Rochelle
AU - Tieman, Ada
AU - Tonascia, James A.
AU - Zheng, Richard
AU - Allan, James
AU - Benz, Wendy K.
AU - Domalpally, Amitha
AU - Johnson, Kristine A.
AU - Myers, Dawn J.
AU - Won Pak, Jeong
AU - Reimers, James L.
AU - Chambers, Geoffrey
AU - Christianson, Debra J.
AU - Fleischli, Margaret A.
AU - Freund, Jacquelyn
AU - Gama, Vonnie
AU - Gangaputra, Sapna
AU - Glander, Kathleen E.
AU - Goulding, Anne
AU - Hafford, Dennis
AU - Harris, Susan E.
AU - Hubbard, Larry D.
AU - Joyce, Jeffrey M.
AU - Kruse, Christina N.
AU - Nagle, Lauren
AU - Padden-Lechten, Gwyn E.
AU - Pohlman, Alyson
AU - Remm, Amy
AU - Shaw, Ruth A.
AU - Sivesind, Peggy
AU - Thayer, Dennis
AU - Treichel, Erika
AU - Warren, Kelly J.
AU - Watson, Sheila M.
AU - Webster, Mary K.
AU - White, James K.
AU - Wilhelmson, Tara
AU - Zhang, Grace
N1 - Publisher Copyright: © 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Purpose To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. Design Cohort study using randomized controlled trial data. Methods Multicenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA. Results Baseline factors significantly associated with reduced BCVA included age ≥50 vs <50 years; posterior vs intermediate uveitis; uveitis duration >10 vs <6 years; anterior chamber (AC) flare >grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P =.52) and 10 letters (P <.001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs <6 years), incident AC flare, cataract at both baseline and follow-up, pseudophakia at baseline, persistence or incidence of vitreous haze, and incidence of macular thickening. Conclusions Intermediate, posterior, and panuveitis have a similarly favorable prognosis with both systemic and fluocinolone acetonide implant treatment. Eyes with more prolonged/severe inflammatory damage and/or inflammatory findings initially or during follow-up have a worse visual acuity prognosis. The results indicate the value of implementing best practices in managing inflammation.
AB - Purpose To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. Design Cohort study using randomized controlled trial data. Methods Multicenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA. Results Baseline factors significantly associated with reduced BCVA included age ≥50 vs <50 years; posterior vs intermediate uveitis; uveitis duration >10 vs <6 years; anterior chamber (AC) flare >grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P =.52) and 10 letters (P <.001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs <6 years), incident AC flare, cataract at both baseline and follow-up, pseudophakia at baseline, persistence or incidence of vitreous haze, and incidence of macular thickening. Conclusions Intermediate, posterior, and panuveitis have a similarly favorable prognosis with both systemic and fluocinolone acetonide implant treatment. Eyes with more prolonged/severe inflammatory damage and/or inflammatory findings initially or during follow-up have a worse visual acuity prognosis. The results indicate the value of implementing best practices in managing inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84951075015&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951075015&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2015.09.017
DO - 10.1016/j.ajo.2015.09.017
M3 - Article
C2 - 26386159
AN - SCOPUS:84951075015
SN - 0002-9394
VL - 160
SP - 1133-1141.e9
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -